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Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome

Author

Listed:
  • Jacopo Mariani

    (EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy)

  • Simona Iodice

    (EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy)

  • Laura Cantone

    (EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy)

  • Giulia Solazzo

    (EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy)

  • Paolo Marraccini

    (Department of Preventive Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy)

  • Emanuele Conforti

    (Department of Preventive Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy)

  • Pallav A. Bulsara

    (GlaxoSmithKline Consumer Healthcare, Warren, NJ 07059, USA)

  • Maria Stella Lombardi

    (GlaxoSmithKline Consumer Healthcare, CH-1260 Nyon, Switzerland)

  • Robert P. Howlin

    (GlaxoSmithKline Consumer Healthcare, Weybridge KT13 0DE, UK)

  • Valentina Bollati

    (EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
    These authors equally contributed to this paper.)

  • Luca Ferrari

    (EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
    These authors equally contributed to this paper.)

Abstract

Particulate matter (PM) exposure is linked to the worsening of respiratory conditions, including allergic rhinitis (AR), as it can trigger nasal and systemic inflammation. To unveil the underlying molecular mechanisms, we investigated the effects of PM exposure on the release of plasmatic extracellular vesicles (EV) and on the complex cross-talk between the host and the nasal microbiome. To this aim, we evaluated the effects of PM 10 and PM 2.5 exposures on both the bacteria-derived-EV portion (bEV) and the host-derived EVs (hEV), as well as on bacterial nasal microbiome (bNM) features in 26 AR patients and 24 matched healthy subjects (HS). In addition, we assessed the role exerted by the bNM as a modifier of PM effects on the complex EV signaling network in the paradigmatic context of AR. We observed that PM exposure differently affected EV release and bNM composition in HS compared to AR, thus potentially contributing to the molecular mechanisms underlying AR. The obtained results represent the first step towards the understanding of the complex signaling network linking external stimuli, bNM composition, and the immune risponse.

Suggested Citation

  • Jacopo Mariani & Simona Iodice & Laura Cantone & Giulia Solazzo & Paolo Marraccini & Emanuele Conforti & Pallav A. Bulsara & Maria Stella Lombardi & Robert P. Howlin & Valentina Bollati & Luca Ferrari, 2021. "Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome," IJERPH, MDPI, vol. 18(20), pages 1-19, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:20:p:10689-:d:654311
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    References listed on IDEAS

    as
    1. Bo Teng & Xuelei Zhang & Chunhui Yi & Yan Zhang & Shufeng Ye & Yafang Wang & Daniel Q. Tong & Binfeng Lu, 2017. "The Association between Ambient Air Pollution and Allergic Rhinitis: Further Epidemiological Evidence from Changchun, Northeastern China," IJERPH, MDPI, vol. 14(3), pages 1-18, February.
    2. Jacopo Mariani & Chiara Favero & Michele Carugno & Laura Pergoli & Luca Ferrari & Matteo Bonzini & Andrea Cattaneo & Angela Cecilia Pesatori & Valentina Bollati, 2020. "Nasal Microbiota Modifies the Effects of Particulate Air Pollution on Plasma Extracellular Vesicles," IJERPH, MDPI, vol. 17(2), pages 1-12, January.
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    Cited by:

    1. Yingjie Liu & Chan Lu & Yuguo Li & Dan Norbäck & Qihong Deng, 2022. "Outdoor Air Pollution and Indoor Window Condensation Associated with Childhood Symptoms of Allergic Rhinitis to Pollen," IJERPH, MDPI, vol. 19(13), pages 1-12, June.

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