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Urinary Proteomics of Simulated Firefighting Tasks and Its Relation to Fitness Parameters

Author

Listed:
  • Ting Zhu

    (School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China
    These authors have contributed equally to this work and were regarded as co–first author.)

  • Yuxiang Hu

    (School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China
    These authors have contributed equally to this work and were regarded as co–first author.)

  • Jooyeon Hwang

    (Department of Occupational and Environmental Health, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA)

  • Dan Zhao

    (Department of Chemistry, Fudan University, Shanghai 200433, China)

  • Libin Huang

    (Baoshan Fire and Rescue Division of Shanghai, Shanghai 201901, China)

  • Liang Qiao

    (Department of Chemistry, Fudan University, Shanghai 200433, China)

  • Ankui Wei

    (School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China)

  • Xin Xu

    (School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China
    Shanghai Anti–Doping Laboratory, Shanghai University of Sport, Shanghai 200438, China)

Abstract

Firefighting rescues are high-hazard activities accompanied by uncertainty, urgency, and complexity. Knowledge of the metabolic characteristics during firefighting rescues is of great value. The purpose of this study was to explore the firefighting-induced physiological responses in greater depth. The urine samples of ten firefighters were collected before and after the simulated firefighting, and the proteins in urine samples were identified by the liquid chromatography–mass spectroscopy. Blood lactate and heart rate were measured. There were 360 proteins up-regulated and 265 proteins downregulated after this simulated firefighting. Changes in protein expression were significantly related to acute inflammatory responses, immune responses, complement activation, and oxidative stress. Beta-2-microglobulin (r = 0.76, p < 0.05) and von Willebrand factors (r = 0.81, p < 0.01) were positively correlated with heart rate during simulated firefighting, and carbonic anhydrase 1 (r = 0.67, p < 0.05) were positively correlated with blood lactate after simulated firefighting. These results illustrated that Beta-2-microglobulin, von Willebrand, and carbonic anhydrase 1 could be regarded as important indicators to evaluate exercise intensity for firefighters.

Suggested Citation

  • Ting Zhu & Yuxiang Hu & Jooyeon Hwang & Dan Zhao & Libin Huang & Liang Qiao & Ankui Wei & Xin Xu, 2021. "Urinary Proteomics of Simulated Firefighting Tasks and Its Relation to Fitness Parameters," IJERPH, MDPI, vol. 18(20), pages 1-16, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:20:p:10618-:d:653238
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    References listed on IDEAS

    as
    1. Jooyeon Hwang & Chao Xu & Robert J. Agnew & Shari Clifton & Tara R. Malone, 2021. "Health Risks of Structural Firefighters from Exposure to Polycyclic Aromatic Hydrocarbons: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(8), pages 1-18, April.
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