IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i19p10098-d643297.html
   My bibliography  Save this article

Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study

Author

Listed:
  • Seyoung Kim

    (National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea)

  • Eunjung Park

    (Hanyang University Institute for Rheumatology Research, Seoul 04763, Korea)

  • Eun-Kyo Park

    (Department of Occupational and Environmental Medicine, Ewha Medical Research Institute, Seoul 07804, Korea)

  • Seulbi Lee

    (Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA)

  • Jeoung-A Kwon

    (Institute of Health Services Research, Yonsei University, Seoul 03722, Korea)

  • Bo-Hye Shin

    (National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea
    Department of Population Health Sciences, Faculty of Life Sciences & Medicine, King’s College London, London WC2R 2LS, UK)

  • Sora Kang

    (Department of Medical Informatics, School of Medicine, Ajou University, Suwon 16499, Korea)

  • Eun-Young Park

    (National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea)

  • Byungmi Kim

    (National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea)

Abstract

Bisphenols are endocrine disruptors that may be associated with altered fetal growth in humans, and they have similar biological functions to mimic hormones. In addition, aggregated chemicals showed an adverse effect although individual concentration was at a low level. However, most studies between bisphenols and birth outcomes have focused on the effect of individual bisphenol. Thus, we explored the associations of urinary bisphenol mixtures with birth outcomes. We conducted a prospective birth cohort study in South Korea. One hundred eighty mother-infant pairs were recruited from 2017 to 2019. Bisphenol A (BPA), bisphenol F (BPF), and bisphenol S (BPS) in one spot urine were analyzed using ultra-performance liquid chromatography–tandem mass spectrometry. We used two statistical approaches to examine potential associations of BPA, BPF, and BPS with birth weight and gestational age: (1) multivariable linear regression; (2) Bayesian kernel machine regression (BKMR). The geometric means of BPA, BPF, and BPS were 2.1, 0.2, and 0.1 μg/L, respectively. In stratified linear analyses by each median value, a higher BPF was positively associated with birth weight (g) (β = 125.5; 95% CI: 45.0 to 205.9). Mixture analyses using BKMR suggested an inverse association between bisphenol mixtures and birth weight. Our findings suggest that in utero bisphenol exposure may influence birth weight and that such relationships may differ considering non-linearity and the combined effect.

Suggested Citation

  • Seyoung Kim & Eunjung Park & Eun-Kyo Park & Seulbi Lee & Jeoung-A Kwon & Bo-Hye Shin & Sora Kang & Eun-Young Park & Byungmi Kim, 2021. "Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study," IJERPH, MDPI, vol. 18(19), pages 1-13, September.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:19:p:10098-:d:643297
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/19/10098/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/19/10098/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:19:p:10098-:d:643297. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.