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Identification of the Prodromal Symptoms and Pre-Ataxic Stage in Cerebellar Disorders: The Next Challenge

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  • Mario Manto

    (Unité des Ataxies Cérébelleuses, Department of Neurology, Médiathèque Jean Jacquy, CHU-Charleroi, 6000 Charleroi, Belgium
    Department of Neurosciences, Université de Mons, 7034 Mons, Belgium)

  • Aasef G. Shaikh

    (Louis Stokes Cleveland VA Medical Center, University Hospitals Cleveland Medical Center, Cleveland, OH 44022, USA)

  • Hiroshi Mitoma

    (Department of Medical Education, Tokyo Medical University, Tokyo 160-0023, Japan)

Abstract

Cerebellar ataxias (CAs) manifest with a combination of motor incoordination, cognitive, affective and recently identified social symptoms. Novel therapies aim to stop the progression of the subgroup of the degenerative ataxias, or even to cure the disease with a functional and anatomical restoration of the cerebellar circuitry in the near future. The goal of stopping the progression of the disease is particularly relevant if applied at a very early stage of the disease, when the cerebellar reserve is only slightly impaired. Therefore, the search of the prodromal phase or pre-ataxic stage of CAs represents a very important challenge for the scientific community. The identification of pre-manifest individuals and the recruitment of individuals at risk has become a key-challenge to address neuroprotective therapies. The feasibility is high due to the recent progress in the biological and morphological biomarkers of CAs.

Suggested Citation

  • Mario Manto & Aasef G. Shaikh & Hiroshi Mitoma, 2021. "Identification of the Prodromal Symptoms and Pre-Ataxic Stage in Cerebellar Disorders: The Next Challenge," IJERPH, MDPI, vol. 18(19), pages 1-7, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:19:p:10057-:d:642601
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    References listed on IDEAS

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    1. Maurice A. Smith & Jason Brandt & Reza Shadmehr, 2000. "Motor disorder in Huntington's disease begins as a dysfunction in error feedback control," Nature, Nature, vol. 403(6769), pages 544-549, February.
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