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A Possible Outbreak by Serratia marcescens : Genetic Relatedness between Clinical and Environmental Strains

Author

Listed:
  • Giuseppina Caggiano

    (Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Francesco Triggiano

    (Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Giusy Diella

    (Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Francesca Apollonio

    (Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Marco Lopuzzo

    (Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Adriana Mosca

    (Department of Interdisciplinary Medicine, Microbiology Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Stefania Stolfa

    (Department of Interdisciplinary Medicine, Microbiology Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Carlo Pazzani

    (Department of Biology, University of Bari Aldo Moro, Via Orabona 4, 70125 Bari, Italy)

  • Marta Oliva

    (Department of Biology, University of Bari Aldo Moro, Via Orabona 4, 70125 Bari, Italy)

  • Carla Calia

    (Department of Biology, University of Bari Aldo Moro, Via Orabona 4, 70125 Bari, Italy)

  • Nicola Laforgia

    (Neonatology and Intensive Care Neonatal Unit Section, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Lidia Dalfino

    (Department of General Surgery, Gynecology and Anaesthesia—Anaesthesia and Intensive Care Unit II, University Hospital Policlinico of Bari, 70124 Bari, Italy)

  • Giovanna Barbuti

    (Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Pasquale Stefanizzi

    (Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Anna Maria Minicucci

    (Health Management, University Hospital Policlinico of Bari, 70124 Bari, Italy)

  • Osvalda De Giglio

    (Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Maria Teresa Montagna

    (Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy)

Abstract

Serratia marcescens (SM) is a Gram-negative bacterium that is frequently found in the environment. Since 1913, when its pathogenicity was first demonstrated, the number of infections caused by SM has increased. There is ample evidence that SM causes nosocomial infections in immunocompromised or critically ill patients admitted to the intensive care units (ICUs), but also in newborns admitted to neonatal ICUs (NICUs). In this study, we evaluated the possible genetic correlation by PFGE between clinical and environmental SM strains from NICU and ICU and compared the genetic profile of clinical strains with strains isolated from patients admitted to other wards of the same hospital. We found distinct clonally related groups of SM strains circulating among different wards of a large university hospital. In particular, the clonal relationship between clinical and environmental strains in NICU and ICU 1 was highlighted. The identification of clonal relationships between clinical and environmental strains in the wards allowed identification of the epidemic and rapid implementation of adequate measures to stop the spread of SM.

Suggested Citation

  • Giuseppina Caggiano & Francesco Triggiano & Giusy Diella & Francesca Apollonio & Marco Lopuzzo & Adriana Mosca & Stefania Stolfa & Carlo Pazzani & Marta Oliva & Carla Calia & Nicola Laforgia & Lidia D, 2021. "A Possible Outbreak by Serratia marcescens : Genetic Relatedness between Clinical and Environmental Strains," IJERPH, MDPI, vol. 18(18), pages 1-9, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:18:p:9814-:d:637832
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    References listed on IDEAS

    as
    1. Maria Luisa Cristina & Marina Sartini & Anna Maria Spagnolo, 2019. "Serratia marcescens Infections in Neonatal Intensive Care Units (NICUs)," IJERPH, MDPI, vol. 16(4), pages 1-10, February.
    2. Maria Teresa Montagna & Francesco Triggiano & Giovanna Barbuti & Nicola Bartolomeo & Osvalda De Giglio & Giusy Diella & Marco Lopuzzo & Serafina Rutigliano & Gabriella Serio & Giuseppina Caggiano, 2019. "Study on the In Vitro Activity of Five Disinfectants against Nosocomial Bacteria," IJERPH, MDPI, vol. 16(11), pages 1-9, May.
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    Cited by:

    1. Francesco Triggiano & Giuseppina Caggiano & Marco Lopuzzo & Giusy Diella & Francesca Apollonio & Fabrizio Fasano & Maria Teresa Montagna, 2022. "No-Touch Automated Disinfection System Based on Hydrogen Peroxide and Ethyl Alcohol Aerosols for Use in Healthcare Environments," IJERPH, MDPI, vol. 19(8), pages 1-6, April.

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