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Cardiorespiratory Fitness and Muscular Strength Moderates the Relationship between FNDC5 Polymorphism and Adiposity in Children and Adolescents

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  • Pâmela Ferreira Todendi

    (Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre—UFCSPA, Sarmento Leite St, 245, Centro Histórico, Porto Alegre 90050-170, Brazil)

  • Caroline Brand

    (Graduate Program in Health Promotion, University of Santa Cruz do Sul, Independência Av. 2293-Universitário, Santa Cruz do Sul 96815-900, Brazil)

  • João Francisco de Castro Silveira

    (Graduate Program in Health Promotion, University of Santa Cruz do Sul, Independência Av. 2293-Universitário, Santa Cruz do Sul 96815-900, Brazil)

  • Ryan Donald Burns

    (Department of Health, Kinesiology, and Recreation, University of Utah, 201 Presidents’ Cir, Salt Lake City, UT 84112, USA)

  • J. Alfredo Martínez

    (Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, 28083 Madrid, Spain)

  • Marilu Fiegenbaum

    (Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre—UFCSPA, Sarmento Leite St, 245, Centro Histórico, Porto Alegre 90690-200, Brazil)

  • Anelise Reis Gaya

    (Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90690-200, Brazil)

  • Jane Dagmar Pollo Renner

    (Graduate Program in Health Promotion, University of Santa Cruz do Sul, Independência Av. 2293-Universitário, Santa Cruz do Sul 96815-900, Brazil)

  • Cézane Priscila Reuter

    (Graduate Program in Health Promotion, University of Santa Cruz do Sul, Independência Av. 2293-Universitário, Santa Cruz do Sul 96815-900, Brazil)

  • Andréia Rosane de Moura Valim

    (Graduate Program in Health Promotion, University of Santa Cruz do Sul, Independência Av. 2293-Universitário, Santa Cruz do Sul 96815-900, Brazil)

Abstract

The human locus FNDC5 rs16835198 contributes positively to anthropometric phenotypes in children and adolescents. However, the role of specific components of physical fitness in this relationship is not known. The present study aimed to verify the moderator role of cardiorespiratory fitness (CRF) and muscular strength in the relationship between rs16835198 polymorphism FNDC5 and adiposity in children and adolescents. This cross-sectional study was carried out by genotyping the rs16835198 FNDC5 polymorphism in 1701 children and adolescents (mean age 11.73 ± 2.75 years). Obesity was assessed using waist circumference and body mass index (BMI) z-scores. To evaluate CRF and muscular strength, the 6 min run/walk test and lower limb strength (LLS) were used. Linear regression models were applied, and all analyses were adjusted for age, sex, skin color, living area, and school type. A significant interaction term for CRF ( p = 0.038) and LLS ( p = 0.040) × rs16835198 FNDC5 with WC was identified. Regarding BMI, a significant interaction term for CRF ( p = 0.007) and LLS ( p = 0.044) × rs16835198 FNDC5 was observed. Moreover, medium and high CRF and LLS levels protected against higher WC and BMI. In conclusion, adiposity levels of children and adolescents with a genetic predisposition to obesity might be modified by improving CRF and muscular strength.

Suggested Citation

  • Pâmela Ferreira Todendi & Caroline Brand & João Francisco de Castro Silveira & Ryan Donald Burns & J. Alfredo Martínez & Marilu Fiegenbaum & Anelise Reis Gaya & Jane Dagmar Pollo Renner & Cézane Prisc, 2021. "Cardiorespiratory Fitness and Muscular Strength Moderates the Relationship between FNDC5 Polymorphism and Adiposity in Children and Adolescents," IJERPH, MDPI, vol. 18(18), pages 1-9, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:18:p:9797-:d:637695
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    References listed on IDEAS

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    1. Glade L. Topham & Isaac J. Washburn & Laura Hubbs-Tait & Tay S. Kennedy & Julie M. Rutledge & Melanie C. Page & Taren Swindle & Lenka H. Shriver & Amanda W. Harrist, 2021. "The Families and Schools for Health Project: A Longitudinal Cluster Randomized Controlled Trial Targeting Children with Overweight and Obesity," IJERPH, MDPI, vol. 18(16), pages 1-13, August.
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    Cited by:

    1. Adriana Berleze & Nadia Cristina Valentini, 2022. "Intervention for Children with Obesity and Overweight and Motor Delays from Low-Income Families: Fostering Engagement, Motor Development, Self-Perceptions, and Playtime," IJERPH, MDPI, vol. 19(5), pages 1-16, February.

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