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Diverse Manifestations of COVID-19: Some Suggested Mechanisms

Author

Listed:
  • Md S. Zaman

    (Department of Biological Sciences, Alcorn State University, Lorman, MS 39096, USA
    Department of Biology, South Texas College, McAllen, TX 78501, USA)

  • Robert C. Sizemore

    (Department of Biological Sciences, Alcorn State University, Lorman, MS 39096, USA)

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the novel respiratory disease COVID-19, has reached pandemic status and presents a wide range of manifestations of diverse magnitude, including fever, cough, shortness of breath, and damage to vital organs, such as the heart, lung, kidney, and brain. Normally, older individuals and those with underlying health issues are more at risk. However, about 40% of COVID-19 positive individuals are asymptomatic. This review aims to identify suggested mechanisms of diverse manifestations of COVID-19. Studies suggest that T cell-mediated immunity and specific and/or nonspecific immunity from other vaccines could protect against SARS-CoV-2. The potential role of cross-reacting antibodies to coronaviruses that cause the common cold, mumps virus, polio virus, and pneumococcal bacteria are also suggested to help protect against COVID-19. Decreased production of Type I interferons (IFN-α and IFN-β) could also be linked to COVID-19 manifestations. Several studies suggest that ACE2 cell membrane receptors are involved in SARS-CoV-2 infection. However, the relationship between an abundance of ACE2 receptors and the infectivity of the virus is unknown. Unlocking these manifestation mysteries could be crucial as this could help researchers better understand the virulence, pathology, and immune responses associated with SARS-CoV-2, leading to the development of effective therapies and treatment plans.

Suggested Citation

  • Md S. Zaman & Robert C. Sizemore, 2021. "Diverse Manifestations of COVID-19: Some Suggested Mechanisms," IJERPH, MDPI, vol. 18(18), pages 1-10, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:18:p:9785-:d:637362
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    References listed on IDEAS

    as
    1. Eric Meffre & Akiko Iwasaki, 2020. "Interferon deficiency can lead to severe COVID," Nature, Nature, vol. 587(7834), pages 374-376, November.
    2. Alice Zwerling & Marcel A. Behr & Aman Verma & Timothy F Brewer & Dick Menzies & Madhukar Pai, 2011. "The BCG World Atlas: A Database of Global BCG Vaccination Policies and Practices," Working Papers id:3921, eSocialSciences.
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