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Validation of an Index for Functionally Important Respiratory Symptoms among Adults in the Nationally Representative Population Assessment of Tobacco and Health Study, 2014–2016

Author

Listed:
  • Michael J. Halenar

    (Westat, Rockville, MD 20850, USA)

  • James D. Sargent

    (Geisel School of Medicine at Dartmouth, The C. Everett Koop Institute at Dartmouth, Hanover, NH 03755, USA)

  • Kathryn C. Edwards

    (Westat, Rockville, MD 20850, USA)

  • Steven Woloshin

    (Dartmouth Institute for Health Policy and Clinical Practice, The C. Everett Koop Institute at Dartmouth, The Lisa Schwartz Foundation, Lebanon, NH 03766, USA)

  • Lisa Schwartz

    (Dartmouth Institute for Health Policy and Clinical Practice, The C. Everett Koop Institute at Dartmouth, The Lisa Schwartz Foundation, Lebanon, NH 03766, USA)

  • Jennifer Emond

    (Geisel School of Medicine at Dartmouth, The C. Everett Koop Institute at Dartmouth, Hanover, NH 03755, USA)

  • Susanne Tanski

    (Geisel School of Medicine at Dartmouth, The C. Everett Koop Institute at Dartmouth, Hanover, NH 03755, USA)

  • John P. Pierce

    (Moores Cancer Center, University of California at San Diego, La Jolla, CA 92037, USA)

  • Kristie A. Taylor

    (Westat, Rockville, MD 20850, USA)

  • Kristin Lauten

    (Westat, Rockville, MD 20850, USA)

  • Maciej L. Goniewicz

    (Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA)

  • Raymond Niaura

    (School of Global Public Health, New York University, New York, NY 10012, USA)

  • Gabriella Anic

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Yanling Chen

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Priscilla Callahan-Lyon

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Lisa D. Gardner

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Theresa Thekkudan

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Nicolette Borek

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Heather L. Kimmel

    (National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20852, USA)

  • K. Michael Cummings

    (Department of Psychiatry & Behavioral Science, Medical University of South Carolina, Mt. Pleasant, SC 29464, USA)

  • Andrew Hyland

    (Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA)

  • Mary F. Brunette

    (Geisel School of Medicine at Dartmouth, The C. Everett Koop Institute at Dartmouth, Hanover, NH 03755, USA)

Abstract

The purpose of this study is to validate the seven-item wheezing module from the International Study of Asthma and Allergies in Children (ISAAC) in the nationally representative Population Assessment of Tobacco and Health Study. Adult participants with complete Wave 2–3 data were selected, including those with asthma but excluding those with COPD and other respiratory diseases ( n = 16,295). We created a nine-point respiratory symptom index from the ISAAC questions, assessed the reliability of the index, and examined associations with self-reported asthma diagnosis. Threshold values were assessed for association with functional outcomes. The weighted prevalence for one or more respiratory symptom was 18.0% (SE = 0.5) for adults without asthma, 70.1% (SE = 1.3) for those with lifetime asthma, 75.7% (SE = 3.7) for adults with past-year asthma not on medications, and 92.6% (SE = 1.6) for those on medications. Cronbach’s alpha for the respiratory symptom index was 0.86. Index scores of ≥2 or ≥3 yielded functionally important respiratory symptom prevalence of 7–10%, adequate sensitivity and specificity for identifying asthma, and consistent independent associations with all functional outcomes and tobacco use variables. Respiratory symptom index scores of ≥2 or ≥3 are indicative of functionally important respiratory symptoms and could be used to assess the relationship between tobacco use and respiratory health.

Suggested Citation

  • Michael J. Halenar & James D. Sargent & Kathryn C. Edwards & Steven Woloshin & Lisa Schwartz & Jennifer Emond & Susanne Tanski & John P. Pierce & Kristie A. Taylor & Kristin Lauten & Maciej L. Goniewi, 2021. "Validation of an Index for Functionally Important Respiratory Symptoms among Adults in the Nationally Representative Population Assessment of Tobacco and Health Study, 2014–2016," IJERPH, MDPI, vol. 18(18), pages 1-13, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:18:p:9688-:d:635461
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