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No Obvious Role for Suspicious Oral Pathogens in Arthritis Development

Author

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  • Poerwati S. Rahajoe

    (Department of Oral and Maxillofacial Surgery, Dr. Sardjito General Hospital, Yogyakarta 55281, Indonesia
    University Medical Center Groningen, Department of Oral and Maxillofacial Surgery, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands)

  • Menke J. de Smit

    (University Medical Center Groningen, Department of Oral and Maxillofacial Surgery, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands)

  • Elisabeth Raveling-Eelsing

    (University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands)

  • Marines du Teil Espina

    (University Medical Center Groningen, Department of Medical Microbiology, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands)

  • Tim Stobernack

    (University Medical Center Groningen, Department of Medical Microbiology, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands)

  • Paola Lisotto

    (University Medical Center Groningen, Department of Medical Microbiology, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands)

  • Hermie J. M. Harmsen

    (University Medical Center Groningen, Department of Medical Microbiology, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands)

  • Jan Maarten van Dijl

    (University Medical Center Groningen, Department of Medical Microbiology, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands)

  • Nyoman Kertia

    (Department of Rheumatology and Clinical Immunology, Dr. Sardjito General Hospital, Yogyakarta 55281, Indonesia)

  • Arjan Vissink

    (University Medical Center Groningen, Department of Oral and Maxillofacial Surgery, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands)

  • Johanna Westra

    (University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands)

Abstract

A particular role for Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) has been suggested in periodontitis and rheumatoid arthritis (RA), as these bacteria could initiate the formation of rheumatoid factor (RF) and anticitrullinated protein autoantibodies (ACPA). We assessed whether serum antibodies against Pg and Aa in RA patients and non-RA controls reflect the subgingival presence of Pg and Aa, and evaluated the relationship of these antibodies to the severity of periodontal inflammation and RA-specific serum autoantibodies. In 70 Indonesian RA patients and 70 non-RA controls, the subgingival presence of Pg and Aa was assessed by bacterial 16S rRNA gene sequencing, and serum IgG levels specific for Pg and Aa were determined. In parallel, serum levels of ACPA (ACPA:IgG,IgA) and RF (RF:IgM,IgA) were measured. The extent of periodontal inflammation was assessed by the periodontal inflamed surface area. In both RA patients and the controls, the presence of subgingival Pg and Aa was comparable, anti-Pg and anti-Aa antibody levels were associated with the subgingival presence of Pg and Aa, and anti-Pg did not correlate with ACPA or RF levels. The subgingival Pg and Aa were not related to RA. No noteworthy correlation was detected between the antibodies against Pg and Aa, and RA-specific autoantibodies.

Suggested Citation

  • Poerwati S. Rahajoe & Menke J. de Smit & Elisabeth Raveling-Eelsing & Marines du Teil Espina & Tim Stobernack & Paola Lisotto & Hermie J. M. Harmsen & Jan Maarten van Dijl & Nyoman Kertia & Arjan Viss, 2021. "No Obvious Role for Suspicious Oral Pathogens in Arthritis Development," IJERPH, MDPI, vol. 18(18), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:18:p:9560-:d:633060
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    References listed on IDEAS

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    1. Menke J. de Smit & Johanna Westra & Marcel D. Posthumus & Gerald Springer & Arie Jan van Winkelhoff & Arjan Vissink & Elisabeth Brouwer & Marc Bijl, 2021. "Effect of Anti-Rheumatic Treatment on the Periodontal Condition of Rheumatoid Arthritis Patients," IJERPH, MDPI, vol. 18(5), pages 1-9, March.
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