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Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort

Author

Listed:
  • Guillaume Sit

    (Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, 94807 Villejuif, France)

  • Noémie Letellier

    (Herbert Wertheim School of Public Health and Human Longevity Science & Scripps, Institution of Oceanography, UC San Diego, La Jolla, CA 92093, USA)

  • Yuriko Iwatsubo

    (Santé publique France Direction Santé Environnement Travail, 94415 Saint-Maurice, France)

  • Marcel Goldberg

    (Population-Based Epidemiological Cohorts Unit, INSERM UMS 11, 94807 Villejuif, France
    Faculty of Medicine, University of Paris, 75006 Paris, France)

  • Bénédicte Leynaert

    (Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, 94807 Villejuif, France)

  • Rachel Nadif

    (Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, 94807 Villejuif, France)

  • Céline Ribet

    (Population-Based Epidemiological Cohorts Unit, INSERM UMS 11, 94807 Villejuif, France)

  • Nicolas Roche

    (Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, 94807 Villejuif, France
    APHP Centre—Université de Paris, Hôpital et Institut Cochin, Service de Pneumologie, 75014 Paris, France)

  • Yves Roquelaure

    (UNIV Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S1085, F-49000 Angers, France)

  • Raphaëlle Varraso

    (Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, 94807 Villejuif, France)

  • Marie Zins

    (Population-Based Epidemiological Cohorts Unit, INSERM UMS 11, 94807 Villejuif, France
    Faculty of Medicine, University of Paris, 75006 Paris, France)

  • Alexis Descatha

    (Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, 94807 Villejuif, France
    UNIV Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S1085, F-49000 Angers, France)

  • Nicole Le Moual

    (Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, 94807 Villejuif, France)

  • Orianne Dumas

    (Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, 94807 Villejuif, France)

Abstract

Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined by participant-reported respiratory symptoms, asthma medication or attacks, and the sum of 5 symptoms, in the past 12 months, respectively. Lifetime exposures to 5 organic solvents, paints and inks were assessed by questionnaire and a population-based Job-Exposure Matrix (JEM). Cross-sectional associations between exposures and outcomes were evaluated by gender using logistic and negative binomial regressions adjusted for age, smoking habits and body mass index. Analyses included 115,757 adults (54% women, mean age 47 years, 9% current asthma). Self-reported exposure to ≥1 solvent was significantly associated with current asthma in men and women, whereas using the JEM, a significant association was observed only in women. Significant associations between exposures to ≥1 solvent and asthma symptom score were observed for both self-report (mean score ratio, 95%CI, women: 1.36, 1.31–1.42; men: 1.34, 1.30–1.40) and JEM (women: 1.10, 1.07–1.15; men: 1.14, 1.09–1.18). Exposure to specific solvents was significantly associated with higher asthma symptom score. Occupational exposure to solvents should be systematically sought when caring for asthma.

Suggested Citation

  • Guillaume Sit & Noémie Letellier & Yuriko Iwatsubo & Marcel Goldberg & Bénédicte Leynaert & Rachel Nadif & Céline Ribet & Nicolas Roche & Yves Roquelaure & Raphaëlle Varraso & Marie Zins & Alexis Desc, 2021. "Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort," IJERPH, MDPI, vol. 18(17), pages 1-13, September.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:17:p:9258-:d:627593
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    References listed on IDEAS

    as
    1. Piero Maestrelli & Paul K. Henneberger & Susan Tarlo & Paola Mason & Piera Boschetto, 2020. "Causes and Phenotypes of Work-Related Asthma," IJERPH, MDPI, vol. 17(13), pages 1-10, June.
    2. Angelica I. Tiotiu & Silviya Novakova & Marina Labor & Alexander Emelyanov & Stefan Mihaicuta & Plamena Novakova & Denislava Nedeva, 2020. "Progress in Occupational Asthma," IJERPH, MDPI, vol. 17(12), pages 1-19, June.
    Full references (including those not matched with items on IDEAS)

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