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Postoperative Drip-Infusion of Remifentanil Reduces Postoperative Pain—A Retrospective Observative Study

Author

Listed:
  • Yi-Hsuan Huang

    (Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan)

  • Meei-Shyuan Lee

    (School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan)

  • Yao-Tsung Lin

    (Department of Anesthesiology, Chi Mei Medical Center, Tainan 71004, Taiwan
    Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan)

  • Nian-Cih Huang

    (Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan)

  • Jing Kao

    (School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan)

  • Hou-Chuan Lai

    (Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan)

  • Bo-Feng Lin

    (Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan)

  • Kuang-I Cheng

    (Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan
    Department of Anesthesiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Zhi-Fu Wu

    (Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
    Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan
    Department of Anesthesiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

Abstract

Development of remifentanil-induced hyperalgesia (RIH) postoperatively is an unpleasant experience that requires further treatment. This study assessed the effects of gradual withdrawal combined with drip infusion of remifentanil on postoperative pain and the requirement for rescue analgesics. A total of 559 patients receiving total intravenous anesthesia with propofol and remifentanil were enrolled. All patients either underwent gradual withdrawal of remifentanil (GWR) or gradual withdrawal combined with drip infusion (GWDR) with a dose of 1 mcg·kg −1 for 30 min after extubation. The numeric rating scale (NRS) and the requirement of rescue analgesics were assessed. The requirement for rescue analgesics was significantly lower in the GWDR group than in the GWR group (13.2% vs. 35.7%; p < 0.001). At the post-anesthetic care unit (PACU), patients in the GWDR group had a lower NRS pain score ( p < 0.001). In addition, in the postoperative 2nd hour, patients in the GWDR group had a significantly lower NRS than the GWR group (beta, −0.31; p = 0.003). No remifentanil-related adverse effects were observed. We found that gradual withdrawal combined with drip infusion of remifentanil required less rescue analgesics and reduced pain scores. The new way of remifentanil administration may be effective to prevent RIH.

Suggested Citation

  • Yi-Hsuan Huang & Meei-Shyuan Lee & Yao-Tsung Lin & Nian-Cih Huang & Jing Kao & Hou-Chuan Lai & Bo-Feng Lin & Kuang-I Cheng & Zhi-Fu Wu, 2021. "Postoperative Drip-Infusion of Remifentanil Reduces Postoperative Pain—A Retrospective Observative Study," IJERPH, MDPI, vol. 18(17), pages 1-12, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:17:p:9225-:d:627037
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    Cited by:

    1. Hou-Chuan Lai & Meng-Fu Lai & Yi-Hsuan Huang & Jyh-Cherng Yu & Wei-Cheng Tseng & Zhi-Fu Wu, 2023. "Comparison of Single Target-Controlled Infusion Pump-Delivered Mixed Propofol and Remifentanil with Two Target-Controlled Infusion Pumps-Delivered Propofol and Remifentanil in Patients Undergoing Brea," IJERPH, MDPI, vol. 20(3), pages 1-14, January.

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