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Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers

Author

Listed:
  • Tatsuya Yoshihara

    (SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan)

  • Masayoshi Zaitsu

    (Department of Public Health, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan)

  • Kazuya Ito

    (SOUSEIKAI Clinical Epidemiological Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
    College of Healthcare Management, Takayanagi 960-4, Setaka-machi, Miyama 835-0018, Japan)

  • Ryuzo Hanada

    (SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan)

  • Eunhee Chung

    (SOUSEIKAI Global Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan)

  • Rie Yazawa

    (SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan)

  • Yukikuni Sakata

    (SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan)

  • Koki Furusho

    (SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan)

  • Hiroshi Tsukikawa

    (SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan)

  • Takeshi Chiyoda

    (SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan)

  • Shunji Matsuki

    (SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan)

  • Shin Irie

    (SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan)

Abstract

The concentration of cerebrospinal fluid total protein (CSF-TP) is important for the diagnosis of neurological emergencies. Recently, some Western studies have shown that the current upper reference limit of CSF-TP is quite low for older patients. However, little is reported about the concentration of CSF-TP in the older Asian population. In this study, we retrospectively analyzed the CSF-TP concentrations in healthy older Japanese volunteers. CSF samples in 69 healthy Japanese volunteers (age range: 55–73 years) were collected by lumbar puncture, and the data of CSF were retrospectively analyzed. The mean (standard deviation) CSF-TP was 41.7 (12.3) mg/dL. The older group (≥65 years old) had higher CSF-TP concentration than the younger group (55–64 years old). The 2.5th percentile and 97.5th percentile of CSF-TP were estimated as 22.5 and 73.2 mg/dL, respectively, which were higher than the current reference range in Japan (10–40 mg/dL). Conclusions: The reference interval of CSF-TP in the older population should be reconsidered for the precise diagnosis of neurological emergencies.

Suggested Citation

  • Tatsuya Yoshihara & Masayoshi Zaitsu & Kazuya Ito & Ryuzo Hanada & Eunhee Chung & Rie Yazawa & Yukikuni Sakata & Koki Furusho & Hiroshi Tsukikawa & Takeshi Chiyoda & Shunji Matsuki & Shin Irie, 2021. "Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers," IJERPH, MDPI, vol. 18(16), pages 1-7, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8683-:d:615923
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