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Novel Therapeutic Targets for the Treatment of Right Ventricular Remodeling: Insights from the Pulmonary Artery Banding Model

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  • Argen Mamazhakypov

    (Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany)

  • Natascha Sommer

    (Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany)

  • Birgit Assmus

    (Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany
    Department of Cardiology, Justus-Liebig University, 35390 Giessen, Germany)

  • Khodr Tello

    (Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany)

  • Ralph Theo Schermuly

    (Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany)

  • Djuro Kosanovic

    (Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany
    Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119992 Moscow, Russia)

  • Akpay Sh. Sarybaev

    (Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek 720040, Kyrgyzstan)

  • Norbert Weissmann

    (Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany)

  • Oleg Pak

    (Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany)

Abstract

Right ventricular (RV) function is the main determinant of the outcome of patients with pulmonary hypertension (PH). RV dysfunction develops gradually and worsens progressively over the course of PH, resulting in RV failure and premature death. Currently, approved therapies for the treatment of left ventricular failure are not established for the RV. Furthermore, the direct effects of specific vasoactive drugs for treatment of pulmonary arterial hypertension (PAH, Group 1 of PH) on RV are not fully investigated. Pulmonary artery banding (PAB) allows to study the pathogenesis of RV failure solely, thereby testing potential therapies independently of pulmonary vascular changes. This review aims to discuss recent studies of the mechanisms of RV remodeling and RV-directed therapies based on the PAB model.

Suggested Citation

  • Argen Mamazhakypov & Natascha Sommer & Birgit Assmus & Khodr Tello & Ralph Theo Schermuly & Djuro Kosanovic & Akpay Sh. Sarybaev & Norbert Weissmann & Oleg Pak, 2021. "Novel Therapeutic Targets for the Treatment of Right Ventricular Remodeling: Insights from the Pulmonary Artery Banding Model," IJERPH, MDPI, vol. 18(16), pages 1-21, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8297-:d:608926
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    References listed on IDEAS

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    1. Ronald J. Vagnozzi & Marjorie Maillet & Michelle A. Sargent & Hadi Khalil & Anne Katrine Z. Johansen & Jennifer A. Schwanekamp & Allen J. York & Vincent Huang & Matthias Nahrendorf & Sakthivel Sadayap, 2020. "An acute immune response underlies the benefit of cardiac stem cell therapy," Nature, Nature, vol. 577(7790), pages 405-409, January.
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