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Future Healthcare Workers and Hepatitis B Vaccination: A New Generation

Author

Listed:
  • Andrea Trevisan

    (Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy)

  • Paola Mason

    (Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy)

  • Annamaria Nicolli

    (Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy)

  • Stefano Maso

    (Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy)

  • Marco Fonzo

    (Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy)

  • Bruno Scarpa

    (Department of Statistical Sciences, University of Padova, 35128 Padova, Italy)

  • Chiara Bertoncello

    (Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy)

Abstract

Before the introduction of universal vaccination, hepatitis B caused high morbidity and mortality, especially among healthcare workers. In the present study, the immune status against hepatitis B was assessed in a cohort of 11,188 students of the degree courses of the School of Medicine of the University of Padua (Italy) who had been subjected to mandatory vaccination in childhood or adolescence and who will be future healthcare workers. The variables that influence the antibody response to vaccination are mainly the age at which the vaccine was administered and sex. If vaccination was administered before one year of age, there is a high probability (around 50%) of having an antibody titer lower than 10 IU/L compared to those vaccinated after one year of age (12.8%). The time between vaccine and analysis is not decisive. Furthermore, female sex, but only if vaccination was administered after one year of age, shows a significant ( p = 0.0008) lower percentage of anti-HBs below 10 IU/L and a greater antibody titer ( p < 0.0001). In conclusion, the differences related to the age of vaccination induce more doubts than answers. The only plausible hypothesis, in addition to the different immune responses (innate and adaptive), is the type of vaccine. This is not easy to verify because vaccination certificates rarely report it.

Suggested Citation

  • Andrea Trevisan & Paola Mason & Annamaria Nicolli & Stefano Maso & Marco Fonzo & Bruno Scarpa & Chiara Bertoncello, 2021. "Future Healthcare Workers and Hepatitis B Vaccination: A New Generation," IJERPH, MDPI, vol. 18(15), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:15:p:7783-:d:599331
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    References listed on IDEAS

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    1. Luca Coppeta & Andrea Pompei & Ottavia Balbi & Ludovico M. De Zordo & Federica Mormone & Sara Policardo & Piergiorgio Lieto & Antonio Pietroiusti & Andrea Magrini, 2019. "Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination," IJERPH, MDPI, vol. 16(9), pages 1-9, April.
    2. Andrea Trevisan & Alessandro Giuliani & Maria Luisa Scapellato & Simona Anticoli & Rita Carsetti & Salvatore Zaffina & Rita Brugaletta & Nicoletta Vonesch & Paola Tomao & Anna Ruggieri, 2020. "Sex Disparity in Response to Hepatitis B Vaccine Related to the Age of Vaccination," IJERPH, MDPI, vol. 17(1), pages 1-10, January.
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    Cited by:

    1. Luca Coppeta & Cristiana Ferrari & Marco Trabucco Aurilio & Gianluigi Ferrazza & Andrea Magrini & Stefano Rizza, 2022. "Night Shift Work Is Associated with Reduced Rate of Humoral Response Following Vaccination for HBV," IJERPH, MDPI, vol. 19(14), pages 1-7, July.

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