IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i14p7574-d595479.html
   My bibliography  Save this article

Adverse Drug Reactions among Children with Tuberculosis in Tashkent, Uzbekistan, 2019

Author

Listed:
  • Makhliyo Abdusalomova

    (Department of Phthisiology and Pulmonology, Tashkent Pediatric Medical Institute, Tashkent 100140, Uzbekistan)

  • Olga Denisiuk

    (Alliance for Public Health, 01601 Kyiv, Ukraine)

  • Hayk Davtyan

    (Tuberculosis Research and Prevention Center, Yerevan 0014, Armenia)

  • Jamshid Gadoev

    (World Health Organization Country Office, Tashkent 100100, Uzbekistan)

  • Barno Abdusamatova

    (Main Department of Protection of Maternity and Childhood, Ministry of Health of Uzbekistan, Tashkent 100011, Uzbekistan)

  • Nargiza Parpieva

    (The Republican Specialized Scientific and Practical Medical Center of Phtisiology and Pulmonology, Tashkent 100179, Uzbekistan)

  • Abduvohid Sodikov

    (The Republican Specialized Scientific and Practical Medical Center of Phtisiology and Pulmonology, Tashkent 100179, Uzbekistan)

Abstract

The treatment of childhood tuberculosis can be challenging due to the lack of pediatric drug formulations and monitoring of drug-toxicity in routine settings. There are no published studies from Uzbekistan on the adverse drug reactions (ADR) associated with anti-tuberculosis treatment in children. In this study, we aimed to investigate the ADR associated with anti-tuberculosis treatment in children. This was a cohort study using secondary program data of children treated at the city and regional tuberculosis clinics in Tashkent, Uzbekistan. Of the 302 patients evaluated, 135 (44.7%) reported ADR. New tuberculosis was registered in 277 (92%) patients and 262 (87%) had extrapulmonary tuberculosis. Factors associated with ADR included treatment at a regional hospital (adjusted odds ratio, aOR = 1.75; p = 0.026), female sex (aOR = 2.2; p = 0.004), and treatment with second-line drugs (aOR = 8.82; p < 0.001). The most common ADRs were gastrointestinal disorders (28.5%) followed by hepatitis (8.9%) and dermatologic reactions (8.6%). Most of the ADRs were mild (55.6%) or moderate (43.7%), only one child had severe ADR. Patients with the identified risk factors should be closely monitored during the treatment. We also recommend expansion of ADR surveillance throughout the country for more representative data in the future.

Suggested Citation

  • Makhliyo Abdusalomova & Olga Denisiuk & Hayk Davtyan & Jamshid Gadoev & Barno Abdusamatova & Nargiza Parpieva & Abduvohid Sodikov, 2021. "Adverse Drug Reactions among Children with Tuberculosis in Tashkent, Uzbekistan, 2019," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7574-:d:595479
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/14/7574/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/14/7574/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7574-:d:595479. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.