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The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects

Author

Listed:
  • Kazuko Kotoku

    (Graduate School of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Johnann-ku, Fukuoka 814-0180, Japan
    Faculty of Fukuoka Medical Technology, Teikyo University, 6-22 Misakimachi, Omuta, Fukuoka 836-8505, Japan)

  • Ryoma Michishita

    (Laboratory of Exercise Physiology, Faculty of Sports of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan
    The Fukuoka University Institute for Physical Activity, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan)

  • Takuro Matsuda

    (Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0133, Japan)

  • Shotaro Kawakami

    (Laboratory of Exercise Physiology, Faculty of Sports of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan
    The Fukuoka University Institute for Physical Activity, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan)

  • Natsumi Morito

    (Fukuoka University Health Care Center, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0133, Japan
    Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0133, Japan)

  • Yoshinari Uehara

    (Laboratory of Exercise Physiology, Faculty of Sports of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan
    The Fukuoka University Institute for Physical Activity, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan)

  • Yasuki Higaki

    (Laboratory of Exercise Physiology, Faculty of Sports of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan
    The Fukuoka University Institute for Physical Activity, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan)

Abstract

Liver fibrosis might be linked to the prevalence of chronic kidney disease (CKD). However, there is little information about the association between liver fibrosis and decreased kidney function in middle-aged and older subjects. We aimed to evaluate the influence of liver fibrosis on the incidence or prevalence of CKD stage 3–5 in a retrospective cross-sectional study (Study 1, n = 806) and a 6-year longitudinal study (Study 2, n = 380) of middle-aged and older subjects. We evaluated liver fibrosis using the Fibrosis-4 (FIB-4) index and kidney function using the estimated glomerular filtration rate (eGFR) of all subjects. All subjects were divided into four groups on the basis of their FIB-4 score quartiles (low to high). In the Jonckheere–Terpstra trend test of Study 1, the eGFR decreased significantly from the lowest group to the highest group ( p < 0.001). The Kaplan–Meier survival curve in Study 2 showed that the cumulative prevalence of CKD stage 3–5 was higher in the third quartile than the other quartiles. Our results suggest that liver fibrosis could be a useful indicator for the prevalence of CKD, even within a relatively healthy population, although liver fibrosis was not an independent risk factor.

Suggested Citation

  • Kazuko Kotoku & Ryoma Michishita & Takuro Matsuda & Shotaro Kawakami & Natsumi Morito & Yoshinari Uehara & Yasuki Higaki, 2021. "The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects," IJERPH, MDPI, vol. 18(13), pages 1-14, June.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:13:p:6980-:d:585059
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