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Serology in COVID-19: Comparison of Two Methods

Author

Listed:
  • Anna Moniuszko-Malinowska

    (Department of Infectious Diseases, Neuroinfections Medical University in Bialystok, Żurawia 14, 15-540 Białystok, Poland)

  • Wojciech Jelski

    (Department of Biochemical Diagnostics, Medical University in Bialystok, Jerzego Waszyngtona 15A, 15-269 Białystok, Poland)

  • Justyna Dunaj

    (Department of Infectious Diseases, Neuroinfections Medical University in Bialystok, Żurawia 14, 15-540 Białystok, Poland)

  • Barbara Mroczko

    (Department of Biochemical Diagnostics, Medical University in Bialystok, Jerzego Waszyngtona 15A, 15-269 Białystok, Poland
    Department of Neurodegeneration Diagnostics, Medical University in Bialystok, Jerzego Waszyngtona 15A, 15-269 Białystok, Poland)

  • Piotr Czupryna

    (Department of Infectious Diseases, Neuroinfections Medical University in Bialystok, Żurawia 14, 15-540 Białystok, Poland)

  • Ewelina Kruszewska

    (Department of Infectious Diseases, Neuroinfections Medical University in Bialystok, Żurawia 14, 15-540 Białystok, Poland)

  • Sławomir Pancewicz

    (Department of Infectious Diseases, Neuroinfections Medical University in Bialystok, Żurawia 14, 15-540 Białystok, Poland)

Abstract

Background: The aim of our study was to examine the performance of two assays in detecting SARS-CoV-2 antibodies. Methods: A total of 127 COVID-19 disease contacts from the Infectious Diseases Department were included. Two serological tests were used: SARS-CoV-2 IgG CMIA on the Alinity system (Abbott) and LIAISON ® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin). Results: The assays exhibited a 96.85% (123/127 patients) test result agreement. In two cases, the positive results obtained by SARS-CoV-2 IgG CMIA on the Alinity system (Abbott) were negative based on the LIAISON ® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin) test, and in two cases, negative results from the LIAISON ® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin) test were positive with the SARS-CoV-2 IgG CMIA on the Alinity system (Abbott). Conclusions: Based on the results of our study, we conclude that in population medicine, the assessments of anti-SARS-CoV-2 antibodies after exposure to SARS-CoV-2 virus based on spike protein or nucleocapsid protein show comparable effectiveness.

Suggested Citation

  • Anna Moniuszko-Malinowska & Wojciech Jelski & Justyna Dunaj & Barbara Mroczko & Piotr Czupryna & Ewelina Kruszewska & Sławomir Pancewicz, 2021. "Serology in COVID-19: Comparison of Two Methods," IJERPH, MDPI, vol. 18(12), pages 1-4, June.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:12:p:6497-:d:575945
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