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Immunohistochemical Expression of Serine and Arginine-Rich Splicing Factor 1 (SRSF1) in Fluoro-Edenite-Induced Malignant Mesothelioma: A Preliminary Study

Author

Listed:
  • Giuseppe Broggi

    (Department of Medical and Surgical Sciences and Advanced Technologies, F. Ingrassia, Anatomic Pathology, University of Catania, 95123 Catania, Italy
    These authors equally contributed to the manuscript.)

  • Giuseppe Angelico

    (Unità di Gineco-patologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
    These authors equally contributed to the manuscript.)

  • Veronica Filetti

    (Human Anatomy and Histology, Department of Biomedical and Biotechnology Sciences, University of Catania, 95123 Catania, Italy)

  • Caterina Ledda

    (Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

  • Claudia Lombardo

    (Human Anatomy and Histology, Department of Biomedical and Biotechnology Sciences, University of Catania, 95123 Catania, Italy)

  • Ermanno Vitale

    (Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

  • Venerando Rapisarda

    (Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

  • Carla Loreto

    (Human Anatomy and Histology, Department of Biomedical and Biotechnology Sciences, University of Catania, 95123 Catania, Italy)

  • Rosario Caltabiano

    (Department of Medical and Surgical Sciences and Advanced Technologies, F. Ingrassia, Anatomic Pathology, University of Catania, 95123 Catania, Italy)

Abstract

The Serine and Arginine-Rich Splicing Factor 1 (SRSF1) has a proto-oncogenic function, being associated with angiogenesis and frequently overexpressed in many human malignant neoplasms. Its immunohistochemical expression has never been investigated in malignant pleural mesothelioma (MPM). We evaluated SRSF1 immunoexpression and its possible relation to angiogenesis in a selected cohort of 10 fluoro-edenite(FE)-induced MPM cases. Methods: Immunohistochemical analyses with an anti-SRSF1 antibody were performed. We interpreted the cases as positive if tumor cell nuclei were stained; a semi-quantitative analysis of the cases was performed by evaluating the intensity of staining and the percentage of tumor positive cells. A microvessel density (MVD) count was also performed. Results: High and low immunoexpressions of SRSF1 were seen in six and four MPMs, respectively. A trend of shorter overall survival was found in FE-induced MPM patients with SRSF1 overexpression. In addition, a significant association between high-MVD and high SRSF1 immunoexpression ( p = 0.0476) was found. Conclusions: SRSF1 appears to be involved in MPM pathogenesis and its immunoexpression may represent a prognostic biomarker capable of identifying subgroups of patients with different prognosis. However, given the preliminary nature of the present study, further investigations on larger series, and additional in vitro studies, are required to validate our findings.

Suggested Citation

  • Giuseppe Broggi & Giuseppe Angelico & Veronica Filetti & Caterina Ledda & Claudia Lombardo & Ermanno Vitale & Venerando Rapisarda & Carla Loreto & Rosario Caltabiano, 2021. "Immunohistochemical Expression of Serine and Arginine-Rich Splicing Factor 1 (SRSF1) in Fluoro-Edenite-Induced Malignant Mesothelioma: A Preliminary Study," IJERPH, MDPI, vol. 18(12), pages 1-8, June.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:12:p:6249-:d:571923
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