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Genetic Variation and Cardiovascular Risk Factors: A Cohort Study on Migrants from the Former Soviet Union and a Native German Population

Author

Listed:
  • Marianne Huebner

    (Institute for Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48864, USA)

  • Daniela Börnigen

    (Bioinformatics Core Facility, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany)

  • Andreas Deckert

    (Institute of Global Health, Epidemiology and Biostatistics, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany)

  • Rolf Holle

    (Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, GmbH, 85764 Neuherberg, Germany)

  • Christa Meisinger

    (German Research Center for Environmental Health, Institute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany)

  • Martina Müller-Nurasyid

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, 85764 Neuherberg, Germany)

  • Annette Peters

    (German Research Center for Environmental Health, Institute of Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany)

  • Wolfgang Rathmann

    (German Center for Diabetes Research (DZD), München-Neuherberg, 85764 Neuherberg, Germany
    German Diabetes Center, Institute for Biometrics and Epidemiology, 40225 Duesseldorf, Germany)

  • Heiko Becher

    (Institute for Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany)

Abstract

Resettlers are a large migrant group of more than 2 million people in Germany who migrated mainly from the former Soviet Union to Germany after 1989. We sought to compare the distribution of the major risk factors for cardiovascular disease (CVD) and to investigate the overall genetic differences in a study population which consisted of resettlers and native (autochthone) Germans. This was a joint analysis of two cohort studies which were performed in the region of Augsburg, Bavaria, Germany, with 3363 native Germans and 363 resettlers. Data from questionnaires and physical examinations were used to compare the risk factors for cardiovascular diseases between the resettlers and native Germans. A population-based genome-wide association analysis was performed in order to identify the genetic differences between the two groups. The distribution of the major risk factors for CVD differed between the two groups. The resettlers lead a less active lifestyle. While female resettlers smoked less than their German counterparts, the men showed similar smoking behavior. SNPs from three genes (BTNL2, DGKB, TGFBR3) indicated a difference in the two populations. In other studies, these genes have been shown to be associated with CVD, rheumatoid arthritis and osteoporosis, respectively.

Suggested Citation

  • Marianne Huebner & Daniela Börnigen & Andreas Deckert & Rolf Holle & Christa Meisinger & Martina Müller-Nurasyid & Annette Peters & Wolfgang Rathmann & Heiko Becher, 2021. "Genetic Variation and Cardiovascular Risk Factors: A Cohort Study on Migrants from the Former Soviet Union and a Native German Population," IJERPH, MDPI, vol. 18(12), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:12:p:6215-:d:571150
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    References listed on IDEAS

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    1. Mary Aparicio & Angela Döring & Andreas Mielck & Rolf Holle, 2005. "Unterschiede zwischen Aussiedlern und der übrigen deutschen Bevölkerung bezüglich Gesundheit, Gesundheitsversorgung und Gesundheitsverhalten: eine vergleichende Analyse anhand des KORA-Surveys 2000," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 50(2), pages 107-118, April.
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