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The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen

Author

Listed:
  • Kamil Gill

    (Department of Histology and Developmental Biology, Pomeranian Medical University, 71-210 Szczecin, Poland)

  • Michal Kups

    (Department of Histology and Developmental Biology, Pomeranian Medical University, 71-210 Szczecin, Poland
    TFP Fertility Vitrolive in Szczecin, 70-483 Szczecin, Poland
    Department of Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, 71-455 Szczecin, Poland)

  • Patryk Harasny

    (Department of Histology and Developmental Biology, Pomeranian Medical University, 71-210 Szczecin, Poland
    Department of Urology and Urological Oncology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland)

  • Tomasz Machalowski

    (Department of Histology and Developmental Biology, Pomeranian Medical University, 71-210 Szczecin, Poland
    Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, 72-010 Police, Poland)

  • Marta Grabowska

    (Department of Histology and Developmental Biology, Pomeranian Medical University, 71-210 Szczecin, Poland)

  • Mariusz Lukaszuk

    (Healthcare Center Nowe Orlowo, 81-525 Gdynia, Poland
    Invicta Fertility Clinic, 80-850 Gdansk, Poland)

  • Marcin Matuszewski

    (Department of Urology, Medical University in Gdansk, 80-214 Gdansk, Poland)

  • Ewa Duchnik

    (Department of Aesthetic Dermatology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland)

  • Monika Fraczek

    (Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland)

  • Maciej Kurpisz

    (Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland)

  • Malgorzata Piasecka

    (Department of Histology and Developmental Biology, Pomeranian Medical University, 71-210 Szczecin, Poland)

Abstract

Since varicocele is so common in infertile men, this study intends to analyse the relationships between varicocele and conventional semen characteristics, sperm nuclear DNA dispersion and oxidation-reduction potential (ORP) in semen. Varicocele-positive and varicocele-negative infertile men (study groups) showed significantly lower standard sperm parameters and higher sperm DNA fragmentation (SDF) and ORP in semen than healthy volunteers and subjects with proven fertility (control groups). A lower proportion of low SDF levels (0–15% SDF) and higher incidence of high SDF levels (>30% SDF), as well as a higher prevalence of high ORP values (>1.37 mV/10 6 sperm/mL), were found in the study groups vs. the control groups. Moreover, infertile men had significantly lower odds ratios (ORs) for low SDF levels and significantly higher ORs for high SDF levels and high ORP. SDF and ORP were negatively correlated with sperm number, morphology, motility and vitality. Furthermore, a significant positive correlation was found between SDF and ORP. The obtained results suggest that disorders of spermatogenesis may occur in varicocele-related infertility. These abnormalities are manifested not only by reduced standard semen parameters but also by decreased sperm DNA integrity and simultaneously increased oxidative stress in semen.

Suggested Citation

  • Kamil Gill & Michal Kups & Patryk Harasny & Tomasz Machalowski & Marta Grabowska & Mariusz Lukaszuk & Marcin Matuszewski & Ewa Duchnik & Monika Fraczek & Maciej Kurpisz & Malgorzata Piasecka, 2021. "The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen," IJERPH, MDPI, vol. 18(11), pages 1-16, June.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5977-:d:567678
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    References listed on IDEAS

    as
    1. Kamil Gill & Joanna Jakubik & Aleksandra Rosiak-Gill & Michał Kups & Mariusz Lukaszuk & Maciej Kurpisz & Monika Fraczek & Małgorzata Piasecka, 2019. "Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential," IJERPH, MDPI, vol. 16(11), pages 1-11, June.
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    Cited by:

    1. Monika Fraczek & Angelika Lewandowska & Marta Budzinska & Marzena Kamieniczna & Lukasz Wojnar & Kamil Gill & Malgorzata Piasecka & Michal Kups & Anna Havrylyuk & Valentina Chopyak & Jozef Nakonechnyy , 2022. "The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress," IJERPH, MDPI, vol. 19(5), pages 1-13, February.

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