IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i11p5861-d565312.html
   My bibliography  Save this article

Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS

Author

Listed:
  • Ayham Daher

    (Department of Pneumology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Christian Cornelissen

    (Department of Pneumology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Niels-Ulrik Hartmann

    (Department of Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Paul Balfanz

    (Department of Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Annegret Müller

    (Department of Pneumology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Ingmar Bergs

    (Department of Pneumology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Maria Aetou

    (Department of Pneumology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Nikolaus Marx

    (Department of Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Gernot Marx

    (Department of Intensive Care and Intermediate Care, University Hospital RWTH, 52074 Aachen, Germany)

  • Tim-Philipp Simon

    (Department of Intensive Care and Intermediate Care, University Hospital RWTH, 52074 Aachen, Germany)

  • Dirk Müller-Wieland

    (Department of Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Bojan Hartmann

    (Department of Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Alexander Kersten

    (Department of Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Tobias Müller

    (Department of Pneumology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

  • Michael Dreher

    (Department of Pneumology and Internal Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, Germany)

Abstract

Although patients who recovered from acute coronavirus disease 2019 (COVID-19) may have prolonged disabilities, follow-up data of those who have survived COVID-19 related acute respiratory distress syndrome (ARDS) is still very scarce. Therefore, COVID-19-ARDS survivors requiring invasive mechanical ventilation (IMV) were followed six months after discharge. Pulmonary function tests (PFTs), 6-min walk test (6MWT) and echocardiography were performed. Quality of life (QoL), depression and anxiety were assessed using validated questionnaires. Patients were compared based on respiratory mechanics and CT-phenotype during intensive care unit (ICU) stay. Eighteen patients were included (61 ± 7 years; ICU-stay: 34 ± 16 days; IMV: 30 ± 15 days). At follow-up (197 ± 15 days after discharge), PFTs did not reveal significant limitations (VC: 92 ± 16%; FEV1: 92 ± 20%; DLco/VA: 81 ± 16%). Cardiac systolic function was normal in all patients, but 50% of them had diastolic dysfunction. 6MWT was under the lower limit of normal in only two patients. Eight patients (44%) reported tiredness, six (33%) suffered from fatigue and one patient (6%) had depression and anxiety. Surprisingly, patients with worse respiratory mechanics during IMV reported fewer symptoms and less exertional dyspnea at follow-up. In conclusion, patients with COVID-19-ARDS have the possibility to fully recover regarding pulmonary function and exercise capacity, which seems to be independent of disease severity during ICU stay.

Suggested Citation

  • Ayham Daher & Christian Cornelissen & Niels-Ulrik Hartmann & Paul Balfanz & Annegret Müller & Ingmar Bergs & Maria Aetou & Nikolaus Marx & Gernot Marx & Tim-Philipp Simon & Dirk Müller-Wieland & Bojan, 2021. "Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS," IJERPH, MDPI, vol. 18(11), pages 1-10, May.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5861-:d:565312
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/11/5861/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/11/5861/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5861-:d:565312. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.