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Phthalate Exposure Pattern in Breast Milk within a Six-Month Postpartum Time in Southern Taiwan

Author

Listed:
  • Shen-Che Hung

    (Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, I-Shou University, Kaohsiung 84001, Taiwan
    These authors contributed equally to this work.)

  • Ting-I Lin

    (Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, I-Shou University, Kaohsiung 84001, Taiwan
    These authors contributed equally to this work.)

  • Jau-Ling Suen

    (Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan)

  • Hsien-Kuan Liu

    (Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, I-Shou University, Kaohsiung 84001, Taiwan)

  • Pei-Ling Wu

    (Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, I-Shou University, Kaohsiung 84001, Taiwan)

  • Chien-Yi Wu

    (Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, I-Shou University, Kaohsiung 84001, Taiwan)

  • Yu-Chen S. H. Yang

    (Joint Biobank, Office of Human Research, Taipei Medical University, Taipei 11031, Taiwan)

  • San-Nan Yang

    (Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, I-Shou University, Kaohsiung 84001, Taiwan)

  • Yung-Ning Yang

    (Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, I-Shou University, Kaohsiung 84001, Taiwan
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

Abstract

Di-(2-ethylhexyl) phthalate (DEHP), a common plasticizer, has been detected in breast milk in many countries; however, whether phthalate metabolite concentration and the detection rate in breast milk change postpartum is still unknown. We measured phthalate metabolite concentrations in breast milk in the first 6 months postpartum in women enrolled in the E-Da hospital from January to July 2017. A total of 56 breastfeeding mothers and 66 samples were included in this study. We analyzed the samples’ concentration of eight phthalate metabolites using liquid chromatography mass spectrometry. The concentration of mono-2-ethylhexyl phthalate (MEHP) was significantly higher in the first month, and then decreased over time. The detection rate of ono-isobutyl phthalate (MiBP) and mono-n-butyl phthalate (MBP) was low in the first month and then increased over time. Compared with a previous study published in 2011, the levels of MEHP and MiBP in breast milk were much lower in the present study, suggesting an increased awareness of the health risks of phthalate exposure after a food scandal occurred in Taiwan. This study provides information for evaluating newborns’ exposure to different kinds of phthalate through human milk in the postpartum period.

Suggested Citation

  • Shen-Che Hung & Ting-I Lin & Jau-Ling Suen & Hsien-Kuan Liu & Pei-Ling Wu & Chien-Yi Wu & Yu-Chen S. H. Yang & San-Nan Yang & Yung-Ning Yang, 2021. "Phthalate Exposure Pattern in Breast Milk within a Six-Month Postpartum Time in Southern Taiwan," IJERPH, MDPI, vol. 18(11), pages 1-12, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5726-:d:562881
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