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Maternal and Neonatal Oral Microbiome Developmental Patterns and Correlated Factors: A Systematic Review—Does the Apple Fall Close to the Tree?

Author

Listed:
  • Gianna Maria Nardi

    (Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy)

  • Roberta Grassi

    (Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy)

  • Artnora Ndokaj

    (Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy)

  • Michela Antonioni

    (Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy)

  • Maciej Jedlinski

    (Department of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland)

  • Gabriele Rumi

    (Foundation Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy)

  • Katarzyna Grocholewicz

    (Department of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland)

  • Irena Dus-Ilnicka

    (Department of Oral Pathology, Wroclaw Medical University, ul. Krakowska 26, 52-425 Wrocław, Poland)

  • Felice Roberto Grassi

    (Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, 70122 Bari, Italy)

  • Livia Ottolenghi

    (Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy)

  • Marta Mazur

    (Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy)

Abstract

(1) Background: The purpose of the study was to comprehensively analyze the relationship between the mother’s oral microbiome, modes of delivery and feeding, and the formation of the newborn child’s oral microbiome. (2) Methods: This systematic review included a search through MEDLINE (PubMed) database (from 2010 to July 2020). Research was registered in PROSPERO under the number CRD42021241044. (3) Results: Of the 571 studies, 11 met the inclusion criteria. Included studies were classified according to (i) child’s delivery mode, (ii) maternal exposure to antibiotics and disinfectants, and (iii) feeding type. (4) Conclusions: The interpretation of these papers shows that the type of delivery, maternal exposure to disinfectants and antibiotics during delivery, maternal health classed as overweight, gestational diabetes mellitus, and feeding type are correlated to changes in the maternal and neonatal early oral microbiomes, based on the analysis provided in this systematic review. Because no evidence exists regarding the impact of maternal diet and maternal oral health on the establishment and development of the early oral newborn microbiome, more studies are needed to deepen the knowledge and understanding of the subject and develop preventive and therapeutic strategies of support to pregnant women.

Suggested Citation

  • Gianna Maria Nardi & Roberta Grassi & Artnora Ndokaj & Michela Antonioni & Maciej Jedlinski & Gabriele Rumi & Katarzyna Grocholewicz & Irena Dus-Ilnicka & Felice Roberto Grassi & Livia Ottolenghi & Ma, 2021. "Maternal and Neonatal Oral Microbiome Developmental Patterns and Correlated Factors: A Systematic Review—Does the Apple Fall Close to the Tree?," IJERPH, MDPI, vol. 18(11), pages 1-14, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5569-:d:560489
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