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Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats

Author

Listed:
  • Ying Xia

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
    The authors contribute equally.)

  • Shanshan Zuo

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
    Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China
    The authors contribute equally.)

  • Yanhua Zheng

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
    The authors contribute equally.)

  • Jin Liu

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China)

  • Wenxiang Yang

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China)

  • Xiaoqiao Tang

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China)

  • Xianghong Ke

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China)

  • Qin Zhuo

    (Key Laboratory of Trace Element Nutrition of National Health Commission (NHC), National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China)

  • Xiaoguang Yang

    (Key Laboratory of Trace Element Nutrition of National Health Commission (NHC), National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China)

  • Yang Li

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China)

  • Bolin Fan

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China)

Abstract

(1) Background: a hybrid black rice rich in β-carotene carrying the psy and crtI genes (HJM) was evaluated in Wistar rats by a 90-day feeding study, aiming to assess its dietary safety. (2) Methods: the HJM rice and its parental line HS were included in rats’ diets at levels of 73.5% and 75.5%, respectively. The AIN-93 diet was administered as a nutritional control. No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed, and standard hematological and biochemical parameters were compared. (3) Results: Some parameters were found to be significantly different, though they remained within the normal range for rats of this breed and age. In addition, upon sacrifice, various organs were weighed, and macroscopic and histopathological examinations were performed, with only minor changes to report. (4) Conclusions: HJM rice exhibited no adverse or toxic effects in Wistar rats in this 90-day study.

Suggested Citation

  • Ying Xia & Shanshan Zuo & Yanhua Zheng & Jin Liu & Wenxiang Yang & Xiaoqiao Tang & Xianghong Ke & Qin Zhuo & Xiaoguang Yang & Yang Li & Bolin Fan, 2021. "Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats," IJERPH, MDPI, vol. 18(11), pages 1-11, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5526-:d:559404
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