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Bone Mineral Density and Hemoglobin Levels: Opposite Associations in Younger and Older Women

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  • Tzyy-Ling Chuang

    (Department of Nuclear Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 622401, Taiwan
    School of Medicine, Tzu Chi University, Hualien 970374, Taiwan)

  • Malcolm Koo

    (Graduate Institute of Long-term Care, Tzu Chi University of Science and Technology, Hualien City, Hualien 973302, Taiwan)

  • Mei-Hua Chuang

    (Faculty of Pharmacy, National Yang-Ming University, Taipei 112304, Taiwan
    Department of Pharmacology, School of Medicine, Tzu Chi University, Hualien 970374, Taiwan)

  • Yuh-Feng Wang

    (Department of Nuclear Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 622401, Taiwan
    School of Medicine, Tzu Chi University, Hualien 970374, Taiwan
    Center of Preventive Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 622401, Taiwan)

Abstract

This cross-sectional, retrospective medical record review study aimed to investigate the association between hemoglobin levels and bone mineral density (BMD) in adult women. Medical records obtained from general health examinations conducted from June 2014 to July 2020 at a regional hospital in southern Taiwan were reviewed. Anthropometric and laboratory data were recorded. BMD of the lumbar spine and bilateral femoral neck regions was assessed by dual energy X-ray absorptiometry. Linear regression analysis was used to assess the association between BMD and hemoglobin level with and without adjusting for other anthropometric and laboratory data. The study included 9606 female patients with a mean age of 55.9 years. Of these, 2756 (28.7%) were aged ≤ 50 years and 6850 (71.3%) were aged > 50 years. Results from multiple linear regression analysis showed that hemoglobin and femoral and lumbar spine BMD were significantly correlated. A higher hemoglobin level was significantly associated with a lower BMD level in females aged ≤ 50 years, but with a higher BMD level in those aged > 50 years. Given the relationship between bone metabolism and hematopoiesis, additional research is needed to elucidate the association between hemoglobin and BMD levels in different age groups, particularly in premenopausal and perimenopausal women.

Suggested Citation

  • Tzyy-Ling Chuang & Malcolm Koo & Mei-Hua Chuang & Yuh-Feng Wang, 2021. "Bone Mineral Density and Hemoglobin Levels: Opposite Associations in Younger and Older Women," IJERPH, MDPI, vol. 18(10), pages 1-11, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:10:p:5495-:d:558812
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    References listed on IDEAS

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    1. Yingli Fu & Yaqin Yu & Shibin Wang & Joseph Sam Kanu & Yueyue You & Yingyu Liu & Yangyu Zhang & Yawen Liu & Bo Li & Yuchun Tao & Changgui Kou, 2016. "Menopausal Age and Chronic Diseases in Elderly Women: A Cross-Sectional Study in Northeast China," IJERPH, MDPI, vol. 13(10), pages 1-11, September.
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