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Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan

Author

Listed:
  • Wen-Chih Wu

    (School of Public Health, National Defense Medical Center, Taipei City 114, Taiwan
    Department of Surgery, Suao and Yuanshan branches of Taipei Veterans General Hospital, Yilan County 270, Taiwan)

  • Yen-Wen Lai

    (Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan)

  • Yu-Ching Chou

    (School of Public Health, National Defense Medical Center, Taipei City 114, Taiwan)

  • Yu-Chan Liao

    (School of Public Health, National Defense Medical Center, Taipei City 114, Taiwan)

  • San-Lin You

    (Department of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan
    Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan)

  • Chyi-Huey Bai

    (School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei City 110, Taiwan)

  • Chien-An Sun

    (Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan
    Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan)

Abstract

Background: Current evidence suggests an association of uric acid with diabetes risk, but it is still unclear whether uric acid is merely a risk marker or an independent risk factor. We evaluate the impact of serum uric acid (SUA) levels on the future risk of developing type 2 diabetes, independent of other factors. Methods: A population-based cohort study was conducted among 4130 participants who were found to be free of type 2 diabetes at baseline recruitment in 2002. Baseline SUA measured in 2002 was longitudinally related to the incident type 2 diabetes that occurred during the follow-up period between 2002 and 2007. Hazard ratios (HRs) and 95% confidence intervals (CIs) derived from Cox proportional hazards models were used to quantify the association. Results: There was a graded increase in the incidence of type 2 diabetes among individuals with increasing levels of SUA. In the whole study cohort, compared to quartile 1, the multivariable-adjusted HRs (95% CIs) of type 2 diabetes in quartile 2, quartile 3, and quartile 4 were 1.69 (0.76–3.76), 1.86 (0.88–4.26), and 1.94 (1.05–4.05), respectively (P for trend = 0.004). This positive gradient for the risk of type 2 diabetes across quartiles of SUA was evident in both genders and across age groups. Conclusions: This study supports that high uric acid concentrations are associated with increased diabetes risk, independent of other known risk factors. These data expand on well-established associations between SUA level and metabolic syndrome, and extend the link to the future risk of type 2 diabetes.

Suggested Citation

  • Wen-Chih Wu & Yen-Wen Lai & Yu-Ching Chou & Yu-Chan Liao & San-Lin You & Chyi-Huey Bai & Chien-An Sun, 2020. "Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan," IJERPH, MDPI, vol. 17(7), pages 1-8, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:7:p:2277-:d:338120
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    References listed on IDEAS

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    1. Qin Lv & Xian-Fang Meng & Fang-Fang He & Shan Chen & Hua Su & Jing Xiong & Pan Gao & Xiu-Juan Tian & Jian-She Liu & Zhong-Hua Zhu & Kai Huang & Chun Zhang, 2013. "High Serum Uric Acid and Increased Risk of Type 2 Diabetes: A Systemic Review and Meta-Analysis of Prospective Cohort Studies," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-7, February.
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