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Influence of Benz[ a ]anthracene on Bone Metabolism and on Liver Metabolism in Nibbler Fish, Girella punctata

Author

Listed:
  • Mohamed I. Zanaty

    (Faculty of Postgraduate Studies for Advanced Sciences, Beni-suef University, Beni-Suef 62511, Egypt
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan)

  • Niina Sawada

    (School of Natural System, College of Science and Engineering, Kanazawa University, Kakuma-machi, Kanazawa city, Ishikawa 920-1192, Japan)

  • Yoichiro Kitani

    (Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan
    School of Natural System, College of Science and Engineering, Kanazawa University, Kakuma-machi, Kanazawa city, Ishikawa 920-1192, Japan)

  • Hossam F. Nassar

    (Faculty of Postgraduate Studies for Advanced Sciences, Beni-suef University, Beni-Suef 62511, Egypt)

  • Hamada M. Mahmoud

    (Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt)

  • Kazuichi Hayakawa

    (Low Level Radioactivity Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Nomi city, Ishikawa 923-1224, Japan)

  • Toshio Sekiguchi

    (Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan
    School of Natural System, College of Science and Engineering, Kanazawa University, Kakuma-machi, Kanazawa city, Ishikawa 920-1192, Japan)

  • Shouzo Ogiso

    (Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan)

  • Yoshiaki Tabuchi

    (Division of Molecular Genetics Research, Life Science Research Center, University of Toyama, Sugitani, Toyama 930-0194, Japan)

  • Makoto Urata

    (Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan
    Institute of Noto SATOUMI Education Research, Noto-cho, Ishikawa 927-0553, Japan)

  • Hajime Matsubara

    (Noto Center for Fisheries Science and Technology, Kanazawa University, Ossaka, Noto-cho, Ishikawa 927-0552, Japan)

  • Yutaka Takeuchi

    (Noto Center for Fisheries Science and Technology, Kanazawa University, Ossaka, Noto-cho, Ishikawa 927-0552, Japan)

  • Atsuhiko Hattori

    (Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa city, Chiba 272-0827, Japan)

  • Ajai K. Srivastav

    (Department of Zoology, D.D.U. Gorakhpur University, Gorakhpur 273-009, India)

  • Thumronk Amornsakun

    (Fisheries Technology Program, Faculty of Science and Technology, Prince of Songkla University, Pattani 94000, Thailand)

  • Nobuo Suzuki

    (Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan
    School of Natural System, College of Science and Engineering, Kanazawa University, Kakuma-machi, Kanazawa city, Ishikawa 920-1192, Japan)

Abstract

It has been reported that spinal deformity was induced in developing fish by the addition of polycyclic aromatic hydrocarbons (PAHs). To examine the mechanism of the disruption of fish bone metabolism, the effect of benz[ a ]anthracene (BaA), a kind of PAH, on plasma calcium, inorganic phosphorus, osteoblasts, and osteoclasts was investigated in this study. We also measured several plasma components to analyze the toxicity of BaA on other metabolisms. BaA (1 or 10 ng/g body weight) was intraperitoneally injected (four times) into nibbler fish during breeding, for 10 days, and it was indicated, for the first time, that injecting high doses of BaA to nibbler fish induced both hypocalcemia and hypophosphatemia. Furthermore, in the scales of nibbler fish treated with high doses of BaA, both osteoclastic and osteoblastic marker messengerRNA (mRNA) expressions decreased. These results are a cause of disruption of bone metabolism and, perhaps, the induction of spinal deformities. In addition, we found that total protein, metabolic enzymes in the liver, total cholesterol, free cholesterol, and high-density lipoprotein cholesterol levels significantly decreased in BaA-injected fish. These results indicate that BaA may affect liver diseases and emphasize the importance of prevention of aquatic PAH pollution.

Suggested Citation

  • Mohamed I. Zanaty & Niina Sawada & Yoichiro Kitani & Hossam F. Nassar & Hamada M. Mahmoud & Kazuichi Hayakawa & Toshio Sekiguchi & Shouzo Ogiso & Yoshiaki Tabuchi & Makoto Urata & Hajime Matsubara & Y, 2020. "Influence of Benz[ a ]anthracene on Bone Metabolism and on Liver Metabolism in Nibbler Fish, Girella punctata," IJERPH, MDPI, vol. 17(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1391-:d:323569
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    Cited by:

    1. Julia Vianna de Pinho & Paloma de Almeida Rodrigues & Ivelise Dimbarre Lao Guimarães & Francielli Casanova Monteiro & Rafaela Gomes Ferrari & Rachel Ann Hauser-Davis & Carlos Adam Conte-Junior, 2022. "The Role of the Ecotoxicology Applied to Seafood as a Tool for Human Health Risk Assessments Concerning Polycyclic Aromatic Hydrocarbons," IJERPH, MDPI, vol. 19(3), pages 1-25, January.

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