IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i4p1269-d321404.html
   My bibliography  Save this article

Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies

Author

Listed:
  • Jan Aaseth

    (Research Department, Innlandet Hospital Trust, 2380 Brumunddal, Norway)

  • Aleksandra Buha

    (Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia)

  • David R. Wallace

    (Center for Health Sciences, School of Biomedical Sciences, Oklahoma State University, Tulsa, OK 74107, USA)

  • Geir Bjørklund

    (Council for Nutritional and Environmental Medicine (CONEM), 8610 Mo i Rana, Norway)

Abstract

Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies. Studies of case records of various tauopathies may reveal clinical phenotype characteristics of the disease. In addition, improved understanding of different tauopathies would disclose environmental factors, such as xenobiotics and trace metals, that can precipitate or modify the progression of the disorder. Important for diagnostics and monitoring of these disorders is a further development of adequate biomarkers, including refined neuroimaging, or proteomics. Our goal is to provide an in-depth review of the current literature regarding the pathophysiological roles of tau proteins and the pathogenic factors leading to various tauopathies, with the perspective of future advances in potential therapeutic strategies.

Suggested Citation

  • Jan Aaseth & Aleksandra Buha & David R. Wallace & Geir Bjørklund, 2020. "Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies," IJERPH, MDPI, vol. 17(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1269-:d:321404
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/4/1269/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/4/1269/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jonathan Baell & Michael A. Walters, 2014. "Chemistry: Chemical con artists foil drug discovery," Nature, Nature, vol. 513(7519), pages 481-483, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jayden Sterling & Jennifer R. Baker & Adam McCluskey & Lenka Munoz, 2023. "Systematic literature review reveals suboptimal use of chemical probes in cell-based biomedical research," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Emmanouil Zacharioudakis & Bogos Agianian & Vasantha Kumar MV & Nikolaos Biris & Thomas P. Garner & Inna Rabinovich-Nikitin & Amanda T. Ouchida & Victoria Margulets & Lars Ulrik Nordstrøm & Joel S. Ri, 2022. "Modulating mitofusins to control mitochondrial function and signaling," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1269-:d:321404. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.