IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i3p800-d313646.html
   My bibliography  Save this article

Economic Evaluation of Hepatitis C Treatment Extension to Acute Infection and Early-Stage Fibrosis Among Patients Who Inject Drugs in Developing Countries: A Case of China

Author

Listed:
  • Yin Liu

    (Department of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
    Sun Yat-sen Center for Migrant Health Policy, Sun Yat-Sen University, Guangzhou 510080, China
    These authors contributed equally to the work.)

  • Hui Zhang

    (Department of Health Policy and Management, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
    These authors contributed equally to the work.)

  • Lei Zhang

    (China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710000, China
    Melbourne Sexual Health Center, Alfred Health, Melbourne VIC 3053, Australia
    Central Clinical School, Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia
    Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Xia Zou

    (Department of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
    Sun Yat-sen Center for Migrant Health Policy, Sun Yat-Sen University, Guangzhou 510080, China)

  • Li Ling

    (Department of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
    Sun Yat-sen Center for Migrant Health Policy, Sun Yat-Sen University, Guangzhou 510080, China)

Abstract

We aimed to assess the cost-effectiveness of (1) treating acute hepatitis C virus (HCV) vs. deferring treatment until the chronic phase and (2) treating all chronic patients vs. only those with advanced fibrosis; among Chinese genotype 1b treatment-naïve patients who injected drugs (PWID), using a combination Daclatasvir (DCV) plus Asunaprevir (ASV) regimen and a Peg-interferon (PegIFN)-based regimen, respectively. A decision-analytical model including the risk of HCV reinfection simulated lifetime costs and quality-adjusted life-years (QALYs) of three treatment timings, under the DCV+ASV and PegIFN regimen, respectively: Treating acute infection (“Treat at acute”), treating chronic patients of all fibrosis stages (“Treat at F0 (no fibrosis)”), treating only advanced-stage fibrosis patients (“Treat at F3 (numerous septa without cirrhosis)”). Incremental cost-effectiveness ratios (ICERs) were used to compare scenarios. “Treat at acute” compared with “Treat at F0” was cost-saving (cost: DCV+ASV regimen—US$14,486.975 vs. US$16,224.250; PegIFN-based regimen—US$19,734.794 vs. US$22,101.584) and more effective (QALY: DCV+ASV regimen—14.573 vs. 14.566; PegIFN-based regimen—14.148 vs. 14.116). Compared with “Treat at F3”; “Treat at F0” exhibited an ICER of US$3780.20/QALY and US$15,145.98/QALY under the DCV+ASV regimen and PegIFN-based regimen; respectively. Treatment of acute HCV infection was highly cost-effective and cost-saving compared with deferring treatment to the chronic stage; for both DCV+ASV and PegIFN-based regimens. Early treatment for chronic patients with DCV+ASV regimen was highly cost-effective.

Suggested Citation

  • Yin Liu & Hui Zhang & Lei Zhang & Xia Zou & Li Ling, 2020. "Economic Evaluation of Hepatitis C Treatment Extension to Acute Infection and Early-Stage Fibrosis Among Patients Who Inject Drugs in Developing Countries: A Case of China," IJERPH, MDPI, vol. 17(3), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:3:p:800-:d:313646
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/3/800/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/3/800/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Guo-Feng Chen & Lai Wei & Jing Chen & Zhong-Ping Duan & Xiao-Guang Dou & Qing Xie & Wen-Hong Zhang & Lun-Gen Lu & Jian-Gao Fan & Jun Cheng & Gui-Qiang Wang & Hong Ren & Jiu-Ping Wang & Xing-Xiang Yang, 2016. "Will Sofosbuvir/Ledipasvir (Harvoni) Be Cost-Effective and Affordable for Chinese Patients Infected with Hepatitis C Virus? An Economic Analysis Using Real-World Data," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-13, June.
    2. Daniëla K van Santen & Anneke S de Vos & Amy Matser & Sophie B Willemse & Karen Lindenburg & Mirjam E E Kretzschmar & Maria Prins & G Ardine de Wit, 2016. "Cost-Effectiveness of Hepatitis C Treatment for People Who Inject Drugs and the Impact of the Type of Epidemic; Extrapolating from Amsterdam, the Netherlands," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-18, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yun Lu & Xiuze Jin & Cheng-a-xin Duan & Feng Chang, 2018. "Cost-effectiveness of daclatasvir plus asunaprevir for chronic hepatitis C genotype 1b treatment-naïve patients in China," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-12, April.
    2. Stephanie Popping & Sebastiaan J Hullegie & Anne Boerekamps & Bart J A Rijnders & Robert J de Knegt & Jürgen K Rockstroh & Annelies Verbon & Charles A B Boucher & Brooke E Nichols & David A M C van de, 2019. "Early treatment of acute hepatitis C infection is cost-effective in HIV-infected men-who-have-sex-with-men," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-15, January.
    3. Anita W M Suijkerbuijk & Albert Jan van Hoek & Jelle Koopsen & Robert A de Man & Marie-Josee J Mangen & Hester E de Melker & Johan J Polder & G Ardine de Wit & Irene K Veldhuijzen, 2018. "Cost-effectiveness of screening for chronic hepatitis B and C among migrant populations in a low endemic country," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-16, November.
    4. Léa Duchesne & Gilles Hejblum & Ndèye Coumba Toure Kane & Richard Njouom & Toni Thomas-d'Aquin & Raoul Moh & Babacar Sylla & Nicolas Rouveau & Alain Attia & Karine Lacombe, 2020. "Model-based cost-effectiveness estimates of testing strategies for diagnosing hepatitis C virus infection in people who use injecting drugs in Senegal," Post-Print hal-02543434, HAL.
    5. Ru Han & Clément François & Mondher Toumi, 2021. "Systematic Review of Health State Utility Values Used in European Pharmacoeconomic Evaluations for Chronic Hepatitis C: Impact on Cost-Effectiveness Results," Applied Health Economics and Health Policy, Springer, vol. 19(1), pages 29-44, January.
    6. Pingyu Chen & Min Jin & Yang Cao & Hongchao Li, 2021. "Cost-Effectiveness Analysis of Oral Direct-Acting Antivirals for Chinese Patients with Chronic Hepatitis C," Applied Health Economics and Health Policy, Springer, vol. 19(3), pages 371-387, May.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:3:p:800-:d:313646. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.