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Evaluation of the Oxidative Stress Status in Zebrafish ( Danio rerio ) Liver Induced by Three Typical Organic UV Filters (BP-4, PABA and PBSA)

Author

Listed:
  • Xinxin Huang

    (School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China)

  • Yuanyuan Li

    (School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China)

  • Tantan Wang

    (School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China)

  • Hui Liu

    (College of Biological and Chemical Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, China)

  • Jiaqi Shi

    (Nanjing Institute of Environmental Sciences of the Ministry of Environmental Protection, Nanjing 210042, Jiangsu, China)

  • Xuesheng Zhang

    (School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China)

Abstract

Organic UV filters are a kind of emerging pollutants, which have been widely used in personal care products (PCPs). This study evaluated the effects of benzophenone-4 (BP-4), 4-aminobenzoic acid (PABA), and 2-phenylbenzimidazole-5-sulfonic acid (PBSA) on the selected indices of antioxidative responses in zebrafish ( Danio rerio ) liver. Zebrafish were exposed to two different doses (i.e., 0.5 and 5 mg L −1 ) of semi-static water with three individual compounds. Liver samples were collected on 7 and 14 days to analyze biochemical indicators, including superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH), and malondialdehyde (MDA). Oxidative stress occurred in zebrafish liver with significantly changed indicators during the whole exposure period. Different experimental groups could induce or inhibit the activity of antioxidant enzymes with varying degrees. With a prolonged exposure time and increased exposure dose, the hepatic lipid peroxidation was also obviously observed. Moreover, the toxicity order of three organic UV filters was analyzed using the integrated biomarker response (IBR) index and the results indicate that exposure to PABA for 7 days at 0.5 mg L −1 and PBSA for 7 days at 5 mg L −1 induced the most severe oxidative stress in the liver of zebrafish.

Suggested Citation

  • Xinxin Huang & Yuanyuan Li & Tantan Wang & Hui Liu & Jiaqi Shi & Xuesheng Zhang, 2020. "Evaluation of the Oxidative Stress Status in Zebrafish ( Danio rerio ) Liver Induced by Three Typical Organic UV Filters (BP-4, PABA and PBSA)," IJERPH, MDPI, vol. 17(2), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:2:p:651-:d:310743
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    References listed on IDEAS

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    1. Alejandro Canales-Aguirre & Eduardo Padilla-Camberos & Ulises Gómez-Pinedo & Hugo Salado-Ponce & Alfredo Feria-Velasco & Ruth De Celis, 2011. "Genotoxic Effect of Chronic Exposure to DDT on Lymphocytes, Oral Mucosa and Breast Cells of Female Rats," IJERPH, MDPI, vol. 8(2), pages 1-14, February.
    2. Aboubacar Younoussa Camara & Yanan Wan & Yao Yu & Qi Wang & Kang Wang & Huafen Li, 2019. "Effect of Endogenous Selenium on Arsenic Uptake and Antioxidative Enzymes in As-Exposed Rice Seedlings," IJERPH, MDPI, vol. 16(18), pages 1-18, September.
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