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Timing of Spheno-Occipital Synchondrosis Ossification in Children and Adolescents with Cleft Lip and Palate: A Retrospective Case-Control Study

Author

Listed:
  • Francisco Vale

    (Faculty of Medicine, Institute of Orthodontics, University of Coimbra, 3000-075 Coimbra, Portugal)

  • Inês Francisco

    (Faculty of Medicine, Institute of Orthodontics, University of Coimbra, 3000-075 Coimbra, Portugal)

  • António Lucas

    (Faculty of Medicine, Institute of Orthodontics, University of Coimbra, 3000-075 Coimbra, Portugal)

  • Ana Roseiro

    (Faculty of Medicine, Institute of Orthodontics, University of Coimbra, 3000-075 Coimbra, Portugal)

  • Francisco Caramelo

    (Faculty of Medicine, Institute of Clinical and Biomedical Research of Coimbra (iCBR), University of Coimbra, 3000-075 Coimbra, Portugal)

  • Adriana Sobral

    (Faculty of Medicine, Institute of Orthodontics, University of Coimbra, 3000-075 Coimbra, Portugal)

Abstract

Background: Cleft lip and palate (CLP) can affect the development of the maxilla; which may create a midfacial deficiency as well as an interference of the facial growth pattern and dentofacial esthetics. Objective: This study aimed to estimate the chronological age of complete fusion of the spheno-occipital synchondrosis (SOS) in cleft lip and palate patients and a control group; using cone beam computed tomography (CBCT) images. Methods: In this retrospective study; 125 patients were enrolled (cleft lip and palate group ( n = 91); control group ( n = 34)). Age comparison was made with a chi-square test; and a Kaplan–Meier analysis determined the median time to reach complete fusion of the spheno-occipital synchondrosis ( p < 0.05). Results: The experimental group showed statistically significant differences in the median time for complete ossification between males and females ( p = 0.019). The median time for complete ossification of the spheno-occipital synchondrosis was; for males; 15.0 years in both groups; for females; it was 14.0 years and 13.0 years in the experimental group and in the control group; respectively. Both for males and females; there were no statistically significant differences between experimental and control groups ( p = 0.104). Conclusions: The present study showed no differences in the ossification of the spheno-occipital synchondrosis between individuals with and without cleft lip and/or palate.

Suggested Citation

  • Francisco Vale & Inês Francisco & António Lucas & Ana Roseiro & Francisco Caramelo & Adriana Sobral, 2020. "Timing of Spheno-Occipital Synchondrosis Ossification in Children and Adolescents with Cleft Lip and Palate: A Retrospective Case-Control Study," IJERPH, MDPI, vol. 17(23), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:23:p:8889-:d:453517
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    Cited by:

    1. Inês Francisco & Gregory S. Antonarakis & Francisco Caramelo & Anabela Baptista Paula & Carlos Miguel Marto & Eunice Carrilho & Maria Helena Fernandes & Francisco Vale, 2022. "Current Treatment of Cleft Patients in Europe from a Provider Perspective: A Cross-Sectional Survey," IJERPH, MDPI, vol. 19(17), pages 1-12, August.

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