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Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study

Author

Listed:
  • Jinsun Kim

    (Division of Cancer Prevention & Early Detection, National Cancer Control Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Korea)

  • Eun Young Park

    (Division of Cancer Prevention & Early Detection, National Cancer Control Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Korea)

  • Eunjung Park

    (Division of Cancer Prevention & Early Detection, National Cancer Control Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Korea)

  • Min Kyung Lim

    (Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do 10408, Korea)

  • Jin-Kyoung Oh

    (Division of Cancer Prevention & Early Detection, National Cancer Control Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Korea
    Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do 10408, Korea)

  • Byungmi Kim

    (Division of Cancer Prevention & Early Detection, National Cancer Control Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Korea)

Abstract

Background: This study aimed to determine the effects of metabolic syndrome (MetS) on colorectal cancer (CRC) using propensity score (PS) methods. Methods: The study subjects were 2417 men and 4568 women from the Korean National Cancer Center (KNCC) Community Cohort enrolled between 2003 and 2010. Odds risks (ORs) and 95% confidence intervals (CIs) using PS matching analysis, regression models adjusted by the PS or stratified into five strata according to PS, and PS weighting methods were calculated. Results: In women, MetS and abnormally high triglyceride (TG) levels were associated with CRC risk using the PS matching analysis (ORs, for MetS, 2.19 (95% CI, 1.10–4.33); for abnormal TG levels, 2.08 (95% CI, 1.07–4.02)). However, there were no significant associations between MetS and TG levels and CRC risk in men. Conclusions: Our study might provide additional evidence that deteriorated metabolic profiles increase the risk of CRC in women rather than men. Thus, this may have an important role in effective population-level interventions for deteriorated metabolic profiles at an early stage.

Suggested Citation

  • Jinsun Kim & Eun Young Park & Eunjung Park & Min Kyung Lim & Jin-Kyoung Oh & Byungmi Kim, 2020. "Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study," IJERPH, MDPI, vol. 17(22), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:22:p:8687-:d:449567
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