IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i18p6926-d417383.html
   My bibliography  Save this article

A Review of Maternal Nutrition during Pregnancy and Impact on the Offspring through Development: Evidence from Animal Models of Over- and Undernutrition

Author

Listed:
  • John F. Odhiambo

    (Division of Agricultural Sciences, Florida A&M University, Tallahassee, FL 32307, USA
    Formerly, Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA)

  • Christopher L. Pankey

    (Formerly, Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA
    Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, WV 24901, USA)

  • Adel B. Ghnenis

    (Formerly, Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA
    Department of Neuroscience and Experimental Therapeutics, Texas A&M University, Bryan, TX 77807, USA)

  • Stephen P. Ford

    (Formerly, Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA
    Author contribution is honored posthumous .)

Abstract

Similarities in offspring phenotype due to maternal under- or over-nutrition during gestation have been observed in studies conducted at University of Wyoming. In these studies, ewes were either nutrient-restricted (NR) from early to mid-gestation, or fed an obesogenic diet (MO) from preconception through term. Offspring necropsies occurred at mid-gestation, late-gestation, and after parturition. At mid gestation, body weights of NR fetuses were ~30% lighter than controls, whereas MO fetuses were ~30% heavier than those of controls. At birth, lambs born to NR, MO, and control ewes exhibited similar weights. This was a consequence of accelerated fetal growth rates in NR ewes, and reduced fetal growth rates in MO ewes in late gestation, when compared to their respective controls. These fetal growth patterns resulted in remarkably similar effects of increased susceptibility to obesity, cardiovascular disease, and glucose intolerance in offspring programmed mostly during fetal stages of development. These data provide evidence that maternal under- and over-nutrition similarly induce the development of the same cadre of physical and metabolic problems in postnatal life.

Suggested Citation

  • John F. Odhiambo & Christopher L. Pankey & Adel B. Ghnenis & Stephen P. Ford, 2020. "A Review of Maternal Nutrition during Pregnancy and Impact on the Offspring through Development: Evidence from Animal Models of Over- and Undernutrition," IJERPH, MDPI, vol. 17(18), pages 1-10, September.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:18:p:6926-:d:417383
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/18/6926/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/17/18/6926/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. repec:mpr:mprres:4039 is not listed on IDEAS
    Full references (including those not matched with items on IDEAS)

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:18:p:6926-:d:417383. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.