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Myocardial Injury and Overload among Amateur Marathoners as Indicated by Changes in Concentrations of Cardiovascular Biomarkers

Author

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  • Anna Maria Kaleta-Duss

    (Department of Cardiology and Electrotherapy, Medical University of Gdańsk, 80-210 Gdańsk, Poland)

  • Zuzanna Lewicka-Potocka

    (Department of Cardiology and Electrotherapy, Medical University of Gdańsk, 80-210 Gdańsk, Poland
    First Department of Cardiology, Medical University of Gdańsk, 80-210 Gdańsk, Poland)

  • Alicja Dąbrowska-Kugacka

    (Department of Cardiology and Electrotherapy, Medical University of Gdańsk, 80-210 Gdańsk, Poland)

  • Grzegorz Raczak

    (Department of Cardiology and Electrotherapy, Medical University of Gdańsk, 80-210 Gdańsk, Poland)

  • Ewa Lewicka

    (Department of Cardiology and Electrotherapy, Medical University of Gdańsk, 80-210 Gdańsk, Poland)

Abstract

Marathons continue to grow in popularity among amateurs. However, the impact of intensive exercise on the amateur’s cardiovascular system has not yet been studied. Analysis of the influence of the marathon on kinetics of biomarkers reflecting cardiac injury and overload may bring new insights into this issue. We investigated the effect of running a marathon on the concentrations of high sensitivity cardiac troponin I (hs-cTnI), heart-type fatty acid binding protein (H-FABP), N-terminal proatrial natriuretic peptide (NT-proANP), B-type natriuretic peptide (BNP), growth differentiation factor 15 (GDF-15) and galectin 3 (Gal-3) in the population of male amateur runners. The study included 35 amateur marathoners and followed 3 stages: S1—two weeks prior to the marathon, S2—at the finish line and S3—two weeks after. Blood samples were collected at each stage and analyzed for biomarkers and laboratory parameters. Concentrations of all studied biomarkers were significantly higher at S2, whereas at S3 did not differ significantly compared to S1. Running a marathon by an amateur causes an acute rise in biomarkers of cardiac injury and stress. Whether repetitive bouts of intensive exercise elicit long-term adverse cardiovascular effects in amateur marathoners needs further research.

Suggested Citation

  • Anna Maria Kaleta-Duss & Zuzanna Lewicka-Potocka & Alicja Dąbrowska-Kugacka & Grzegorz Raczak & Ewa Lewicka, 2020. "Myocardial Injury and Overload among Amateur Marathoners as Indicated by Changes in Concentrations of Cardiovascular Biomarkers," IJERPH, MDPI, vol. 17(17), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:17:p:6191-:d:404406
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    Cited by:

    1. Damien Vitiello & Florent Palacin & Luc Poinsard & Marine Kirsch & Steeve Jouini & Véronique Billat, 2021. "Marathon-Induced Cardiac Fatigue: A Review over the Last Decade for the Preservation of the Athletes’ Health," IJERPH, MDPI, vol. 18(16), pages 1-11, August.

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