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Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?

Author

Listed:
  • Aneta Słabuszewska-Jóżwiak

    (First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Żelazna 90 Street, 01-004 Warsaw, Poland)

  • Marta Włodarczyk

    (Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland
    Center for Preclinical Research, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland)

  • Krzysztof Kilian

    (Heavy Ion Laboratory, University of Warsaw, Pasteura 5a Street, 02-093 Warsaw, Poland)

  • Zbigniew Rogulski

    (Radiochemistry for Medicine and Industry, Biological and Chemical Research Centre, University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland)

  • Michał Ciebiera

    (Second Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Cegłowska 80 Street, 01-809 Warsaw, Poland)

  • Jolanta Szymańska-Majchrzak

    (Chair and Department of Biochemistry, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland)

  • Kornelia Zaręba

    (First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Żelazna 90 Street, 01-004 Warsaw, Poland)

  • Jacek Krzysztof Szymański

    (First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Żelazna 90 Street, 01-004 Warsaw, Poland)

  • Dorota Raczkiewicz

    (Institute of Statistics and Demography, Collegium of Economic Analysis, SGH Warsaw School of Economics, Madalińskiego 6/8 Street, 02-513 Warsaw, Poland)

  • Grażyna Nowicka

    (Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland
    Center for Preclinical Research, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland)

  • Grzegorz Jakiel

    (First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Żelazna 90 Street, 01-004 Warsaw, Poland)

Abstract

Purpose: Comparison of the activity of 11beta-hydroxysteroid dehydrogenase type 2 in the placenta and the umbilical cord blood cortisol level between caesarean sections with or without uterine contraction and vaginal delivery groups. Cortisol is the main stress hormone responsible for the normal adaptation of the neonate to extrauterine life. The disorders resulting from a dysfunction of the 11β-HSD 2–cortisol system can explain the higher risk of developing diseases in children born by caesarean section. Methods: 111 healthy, pregnant women in singular pregnancy at term of delivery were included into the study. The study comprised 11β-HSD 2 in placental tissue from 49 pregnant women delivering by elective caesarean section and 46 pregnant women delivering by vagina. In 16 cases of the elective caesarean section, regular uterine contractions were declared. Cortisol level was estimated in umbilical cord blood directly after delivery. Results: We found no statistically significant differences in the activity of 11β-HSD 2 in placentas delivered via caesarean sections (29.61 on average in elective caesarean sections and 26.65 on average in intrapartum caesarean sections) compared to vaginal deliveries (31.94 on average, p = 0.381), while umbilical cord blood cortisol in the elective caesarean sections group was significantly lower (29.86 on average) compared to the vaginal deliveries (55.50 on average, p < 0.001) and intrapartum caesarean sections (52.27 on average, p < 0.001). Conclusions: The model of placental 11β-HSD 2 activity and umbilical cord blood cortisol concentration seems to be significant in conditions of stress associated with natural uterine contractions in labour.

Suggested Citation

  • Aneta Słabuszewska-Jóżwiak & Marta Włodarczyk & Krzysztof Kilian & Zbigniew Rogulski & Michał Ciebiera & Jolanta Szymańska-Majchrzak & Kornelia Zaręba & Jacek Krzysztof Szymański & Dorota Raczkiewicz , 2020. "Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?," IJERPH, MDPI, vol. 17(15), pages 1-13, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:15:p:5566-:d:393295
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    Citations

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    Cited by:

    1. Aneta Słabuszewska-Jóźwiak & Jacek Krzysztof Szymański & Michał Ciebiera & Beata Sarecka-Hujar & Grzegorz Jakiel, 2020. "Pediatrics Consequences of Caesarean Section—A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(21), pages 1-17, October.
    2. Masako Aoki & Tatsuhiko Urakami & Nobuhiko Nagano & Ryoji Aoki & Ichiro Morioka, 2022. "Association of Plasma Cortisol Levels with Gestational Age and Anthropometric Values at Birth in Preterm Infants," IJERPH, MDPI, vol. 19(18), pages 1-11, September.
    3. Rosaria Cappadona & Sara Puzzarini & Vanessa Farinelli & Piergiorgio Iannone & Alfredo De Giorgi & Emanuele Di Simone & Roberto Manfredini & Rosita Verteramo & Pantaleo Greco & María Aurora Rodríguez , 2020. "Daylight Saving Time and Spontaneous Deliveries: A Case–Control Study in Italy," IJERPH, MDPI, vol. 17(21), pages 1-9, November.

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