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Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60–75 Years

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  • Aleksandra Rył

    (Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, Żolnierska 48, 71-210 Szczecin, Poland)

  • Aleksandra Szylińska

    (Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, Żolnierska 48, 71-210 Szczecin, Poland)

  • Alina Jurewicz

    (Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland)

  • Andrzej Bohatyrewicz

    (Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland)

  • Tomasz Miazgowski

    (Department of Hypertension and Internal Medicine, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland)

  • Iwona Rotter

    (Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, Żolnierska 48, 71-210 Szczecin, Poland)

Abstract

Introduction : The purpose of this study was to analyze the relationship between the parameters of bone turnover and the levels of hormonal parameters, such as total testosterone (TT), bioavailable and free testosterone (FT), and estradiol (E2) in men. Material and methods : The study group included 63 men with testosterone deficiency syndrome (TDS). The control group consisted of 112 patients without TDS. Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of osteocalcin (OC), parathyroid hormone (PTH), E2, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS), insulin (I), Serum CrossLaps (CtX-I), human procollagen I N-terminal peptide (PINP), and TT. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Results : The groups with TSD and without TDS differed in terms of the following parameters: body weight ( p = 0.001), BMI ( p = 0.003), TT ( p = 0.001), FT ( p = 0.004), bioavailable testosterone ( p = 0.001), E2 ( p = 0.003), SHBG ( p = 0.003), and PINP ( p = 0.004). In the group without TDS, higher PINP levels were accompanied by higher levels of E2 (beta = 0.360, p = 0.002) and TT (beta = 0.389, p = 0.001). In the group without TDS, PINP was positively correlated with E2 (beta = 0.726, p <0.001). Patients with TDS had significantly lower PINP levels ( p < 0.004). Conclusions : Analysis of sex hormones and biochemical bone markers in reflecting the quality of the bone tissue in men may suggest a relationship between these parameters. Nevertheless, further research based on a larger sample size is necessary to better describe this relationship.

Suggested Citation

  • Aleksandra Rył & Aleksandra Szylińska & Alina Jurewicz & Andrzej Bohatyrewicz & Tomasz Miazgowski & Iwona Rotter, 2019. "Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60–75 Years," IJERPH, MDPI, vol. 17(1), pages 1-12, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2019:i:1:p:106-:d:300837
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    References listed on IDEAS

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    1. Andrea Palermo & Dario Tuccinardi & Giuseppe Defeudis & Mikiko Watanabe & Luca D’Onofrio & Angelo Lauria Pantano & Nicola Napoli & Paolo Pozzilli & Silvia Manfrini, 2016. "BMI and BMD: The Potential Interplay between Obesity and Bone Fragility," IJERPH, MDPI, vol. 13(6), pages 1-30, May.
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