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Association of ACTN3 Polymorphism with Body Somatotype and Cardiorespiratory Fitness in Young Healthy Adults

Author

Listed:
  • Natalia Potocka

    (Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland
    These authors contributed equally to this manuscript.)

  • Beata Penar-Zadarko

    (Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland
    Innovative Research Laboratory in Nursing, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland
    These authors contributed equally to this manuscript.)

  • Marzena Skrzypa

    (Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland
    These authors contributed equally to this manuscript.)

  • Marcin Braun

    (Department of Pathology, Chair of Oncology, Medical University of Lodz, 90-419 Lodz, Poland
    Postgraduate School of Molecular Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland)

  • Maria Zadarko-Domaradzka

    (Department of Human Sciences, Faculty of Physical Education, University of Rzeszow, 35-959 Rzeszow, Poland)

  • Mariusz Ozimek

    (Institute of Sport-National Research Institute, 02-091 Warsaw, Poland)

  • Edyta Nizioł-Babiarz

    (Department of Health Sciences, Faculty of Physical Education, University of Rzeszow, 35-959 Rzeszow, Poland)

  • Zbigniew Barabasz

    (Department of Health Sciences, Faculty of Physical Education, University of Rzeszow, 35-959 Rzeszow, Poland)

  • Izabela Zawlik

    (Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland
    Department of Genetics, Institution of Experimental and Clinical Medicine, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland)

  • Emilian Zadarko

    (Department of Health Sciences, Faculty of Physical Education, University of Rzeszow, 35-959 Rzeszow, Poland)

Abstract

ACTN3 encodes the protein α-actinin-3, which affects the muscle phenotype. In the present study, we examined the association of ACTN3 R577X polymorphism with body somatotype and cardiorespiratory fitness in young, healthy adults. The study group included 304 young adults, in whom cardiorespiratory fitness was evaluated and the maximum oxygen uptake was determined directly. The somatotype components were calculated according to the Heath-Carter method. Genotyping for the ACTN3 gene was performed using a polymerase chain reaction followed by high-resolution melting analysis. In the female group, a lower maximal heart rate (HRmax) was more strongly associated with the RR genotype ( p = 0.0216) than with the RX and XX genotypes. In the male group, the ACTN3 RX genotype, as compared with other genotypes, tended to be associated with a lower percentage of adipose tissue ( p = 0.0683), as also reflected by the body mass index ( p = 0.0816). ACTN3 gene polymorphism may affect cardiorespiratory fitness. Our analysis of ACTN3 gene polymorphism does not clearly illustrate the relationships among genotype, body composition, and somatotype in young, healthy adults.

Suggested Citation

  • Natalia Potocka & Beata Penar-Zadarko & Marzena Skrzypa & Marcin Braun & Maria Zadarko-Domaradzka & Mariusz Ozimek & Edyta Nizioł-Babiarz & Zbigniew Barabasz & Izabela Zawlik & Emilian Zadarko, 2019. "Association of ACTN3 Polymorphism with Body Somatotype and Cardiorespiratory Fitness in Young Healthy Adults," IJERPH, MDPI, vol. 16(9), pages 1-12, April.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:9:p:1489-:d:226372
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