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Effects of Long Noncoding RNA H19 Polymorphisms on Urothelial Cell Carcinoma Development

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  • Po-Jen Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    These authors contributed equally to the work.)

  • Ming-Ju Hsieh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
    Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    These authors contributed equally to the work.)

  • Tung-Wei Hung

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Nephrology, Department of Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Shian-Shiang Wang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, Taiwan)

  • Shiuan-Chih Chen

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Meng-Chih Lee

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung 403, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Ying-Erh Chou

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

Urothelial cell carcinoma (UCC) is one of the major malignancies of the genitourinary tract, and it is induced by carcinogenic epidemiological risk factors. H19 is one of the most crucial long noncoding RNAs (lncRNAs) and is involved in various types of bladder cancer. In this study, we examined H19 single-nucleotide polymorphisms (SNPs) to investigate UCC susceptibility and clinicopathological characteristics. Using real-time polymerase chain reaction, we analyzed five SNPs of H19 in 431 UCC patients and 431 controls without cancer. The results showed that patients with UCC carrying the H19 rs217727 CT + TT and rs2107425 CT + TT genetic variants had a high risk of developing muscle invasive tumors (pT2–T4) ( p = 0.030; p = 0.025, respectively). With a median follow up of 39 months, CT+TT polymorphisms of rs2107425 were associated with worse disease-specific survival (adjusted hard ratio (AHR) = 2.043, 95% confidence interval (CI) = 1.029-4.059) in UCC patients aged older than 65 years. In conclusion, our results indicate that patients with UCC carrying the H19 rs217727 CT + TT and rs2107425 CT + TT genetic variants have a high risk of developing muscle invasive tumors. Thus, H19 polymorphisms may be applied as a marker or therapeutic target in UCC treatment.

Suggested Citation

  • Po-Jen Yang & Ming-Ju Hsieh & Tung-Wei Hung & Shian-Shiang Wang & Shiuan-Chih Chen & Meng-Chih Lee & Shun-Fa Yang & Ying-Erh Chou, 2019. "Effects of Long Noncoding RNA H19 Polymorphisms on Urothelial Cell Carcinoma Development," IJERPH, MDPI, vol. 16(8), pages 1-10, April.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:8:p:1322-:d:222338
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    Citations

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    Cited by:

    1. Yao-Chen Wang & Shih-Ming Tsao & Yia-Ting Li & Chia-Yi Lee & Thomas Chang-Yao Tsao & Ming-Ju Hsieh & Shun-Fa Yang, 2021. "The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma," IJERPH, MDPI, vol. 18(6), pages 1-12, March.

    More about this item

    Keywords

    urothelial cell carcinoma; polymorphism; H19; lncRNA;
    All these keywords.

    JEL classification:

    • H19 - Public Economics - - Structure and Scope of Government - - - Other

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