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The Development of Keratopathy after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

Author

Listed:
  • Hung-Jui Hsu

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    These authors contributed equally to the work.)

  • Chia-Yi Lee

    (Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    Department of Optometry, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan 717, Taiwan
    These authors contributed equally to the work.)

  • Kun-Lin Yang

    (Department of Otolaryngology–Head and Neck Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan)

  • Hung-Chi Chen

    (Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333, Taiwan
    Department of Medicine, Chang Gung University College of Medicine, Taoyuan 333, Taiwan
    Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 333, Taiwan)

  • Chi-Chin Sun

    (Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 204, Taiwan
    Department of Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan)

  • Jing-Yang Huang

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Hung-Yu Lin

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    Department of Optometry, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Exercise and Health Promotion, Chung Chou University of Science and Technology, Changhua 500, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

The aim of the present study was to evaluate the risk of developing keratopathy in patients with surgery-indicated chronic rhinosinusitis (CRS) via the National Health Insurance Research Database in Taiwan. Patients with a diagnostic code of CRS and who received functional endoscopic sinus surgery (FESS) were considered to have surgery-indicated CRS. The exclusion criteria were legal blindness, an ocular tumor, eyeball removal or previous keratopathy, and each individual in the study group was matched to four non-CRS patients by age and sex. The outcome was set as the occurrence of keratopathy according to the diagnostic codes after the index date. Cox proportional hazard regression was used for statistical analysis. A total of 6053 patients with surgery-indicated CRS and another 24,212 non-CRS individuals were enrolled after exclusions. The age and sex distributions were identical between the two groups due to matching, while comorbidities, including hypertension, diabetes mellitus, and other cardiovascular disorders, were significantly higher in the study group. There were 231 episodes of keratopathy in the study group, and 695 episodes of keratopathy in the control group after the index date, for which study group showed a significantly higher rate of developing keratopathy with an adjusted hazard ratio of 1.208 and a higher cumulative probability. In subgroup analysis, female sex with surgery-indicated CRS showed a significantly greater risk of developing keratopathy. In conclusion, surgery-indicated CRS that needs FESS to relieve symptoms is a potential risk factor for keratopathy.

Suggested Citation

  • Hung-Jui Hsu & Chia-Yi Lee & Kun-Lin Yang & Hung-Chi Chen & Chi-Chin Sun & Jing-Yang Huang & Hung-Yu Lin & Shun-Fa Yang, 2019. "The Development of Keratopathy after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study," IJERPH, MDPI, vol. 16(7), pages 1-9, April.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:7:p:1218-:d:220218
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    Cited by:

    1. Siu-Fung Chau & Pei-Hsuan Wu & Chi-Chin Sun & Jing-Yang Huang & Chan-Wei Nien & Shun-Fa Yang & Ming-Chih Chou & Pei-Ting Lu & Hung-Chi Chen & Chia-Yi Lee, 2019. "The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study," IJERPH, MDPI, vol. 16(22), pages 1-12, November.

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