IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i6p995-d215355.html
   My bibliography  Save this article

Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles

Author

Listed:
  • Cheng-Hsuan Wu

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Women’s Health Research Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan
    School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Tsung-Hsien Lee

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
    These two authors contributed equally to this work.)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Hui-Mei Tsao

    (Division of Infertility Clinic, Lee Womens’ Hospital, Taichung 406, Taiwan)

  • Yu-Jun Chang

    (Epidemiology and Biostatistics Center, Changhua Christian Hospital, Changhua 50006, Taiwan)

  • Chia-Hsuan Chou

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Maw-Sheng Lee

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
    Division of Infertility Clinic, Lee Womens’ Hospital, Taichung 406, Taiwan
    These two authors contributed equally to this work.)

Abstract

The aim of this study was to examine the association between interleukin (IL) genes polymorphisms and in vitro fertilization (IVF) outcome. A prospective cohort analysis was performed at a Women’s Hospital IVF centre of 1015 female patients undergoing fresh non-donor IVF cycles. The effects of the following six single nucleotide polymorphisms (SNPs) in five IL genes on IVF outcomes were explored: IL-1α (rs1800587 C/T), IL-3 (rs40401 C/T), IL-6 (rs1800795 C/G), IL-15 (rs3806798 A/T), IL-18 (rs187238 C/G) and IL-18 (rs1946518 G/T). The main outcome measures included clinical pregnancy, embryo implantation, abortion and live birth rates. There were no statistically significant differences in clinical pregnancy, embryo implantation and live birth rates in the analysis of 1015 patients attempting their first cycle of IVF. Infertile women with IL-3 homozygous major genotype had a higher abortion rate than those with heterozygous and homozygous minor genotype (16.5% vs. 7.9%, P = 0.025). In conclusion, our results indicated that the IL-3 rs40401 polymorphism is associated with increased risk of abortion of IVF patients. Future studies with inclusion of other ethnic populations must be conducted to confirm the findings of this study.

Suggested Citation

  • Cheng-Hsuan Wu & Tsung-Hsien Lee & Shun-Fa Yang & Hui-Mei Tsao & Yu-Jun Chang & Chia-Hsuan Chou & Maw-Sheng Lee, 2019. "Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles," IJERPH, MDPI, vol. 16(6), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:6:p:995-:d:215355
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/6/995/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/6/995/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chien-Lung Chan & Chi-Chang Chang, 2020. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 17(18), pages 1-7, September.
    2. Chien-Lung Chan & Chi-Chang Chang, 2022. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 19(14), pages 1-9, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:6:p:995-:d:215355. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.