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Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice

Author

Listed:
  • Xiping Yi

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China
    These two authors contributed equally to this work.)

  • Shuaishuai Xu

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China
    These two authors contributed equally to this work.)

  • Feiyu Huang

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China)

  • Cong Wen

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China)

  • Shuilin Zheng

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China)

  • Hai Feng

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China)

  • Jian Guo

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China)

  • Jihua Chen

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China)

  • Xiangling Feng

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China)

  • Fei Yang

    (Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China
    Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health Southeast University, Nanjing 210009, China
    Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, Central South University, Changsha 410083, China)

Abstract

Microcystin-LR (MC-LR) is a potent hepatotoxin, but a few studies suggested that it might also induce nephrotoxicity. However, nephrotoxicity induced by prolonged oral exposure to MC-LR is unknown. The aim of this study was to evaluate the potential influence of MC-LR on the kidney in mice following chronic exposure to MC-LR. In this study, we evaluated the nephrotoxicity of MC-LR in mice drinking water at different concentrations (1, 30, 60, 90, and 120 μg/L) for 6 months for the first time. The results showed that the kidney weights and the kidney indexes of mice were not altered in the MC-LR treated mice, compared with the control group. In addition, the renal function indicators revealed that the serum creatinine (SCr) levels were not significant changes after exposure to MC-LR. The blood urea nitrogen (BUN) levels were markedly decreased after exposure to 90 and 120 μg/L MC-LR for 3 months. The BUN levels were lower than that of the control group after exposure to 120 μg/L MC-LR for 6 months. The histopathological investigation revealed enlarged renal corpuscles, widened of kidney tubules, and lymphocyte infiltration in the interstitial tissue and the renal pelvis after exposure to 60, 90, and 120 μg/L MC-LR. Consequently, our results suggested that long-term exposure to MC-LR might be one important risk of kidney injury, which will provide important clues for the prevention of renal impairment.

Suggested Citation

  • Xiping Yi & Shuaishuai Xu & Feiyu Huang & Cong Wen & Shuilin Zheng & Hai Feng & Jian Guo & Jihua Chen & Xiangling Feng & Fei Yang, 2019. "Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice," IJERPH, MDPI, vol. 16(24), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:24:p:5030-:d:296323
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    Cited by:

    1. Wenqing Xiao & Qing Zhong & Feng Sun & Weiguang Wang & Zhiyao Zhao & Kangding Gu, 2021. "Differences in Abnormal Water Metabolism between SD Rats and KM Mice Intoxicated by Microcystin-RR," IJERPH, MDPI, vol. 18(4), pages 1-22, February.

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