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Urban Air Pollution Particulates Suppress Human T-Cell Responses to Mycobacterium Tuberculosis

Author

Listed:
  • Olufunmilola Ibironke

    (Physiology and Integrative Biology, Rutgers University, Piscataway, NJ 08854, USA)

  • Claudia Carranza

    (Department of Microbiology, National Institute of Respiratory Diseases (INER), Mexico City 1408, Mexico)

  • Srijata Sarkar

    (Environmental and Occupational Health Sciences Institute, Rutgers, Piscataway, NJ 08854, USA)

  • Martha Torres

    (Department of Microbiology, National Institute of Respiratory Diseases (INER), Mexico City 1408, Mexico)

  • Hyejeong Theresa Choi

    (Environmental and Occupational Health Sciences Institute, Rutgers, Piscataway, NJ 08854, USA)

  • Joyce Nwoko

    (Department of Environmental and Occupational Health, Rutgers School of Public Health, Piscataway, NJ 08854, USA)

  • Kathleen Black

    (Environmental and Occupational Health Sciences Institute, Rutgers, Piscataway, NJ 08854, USA)

  • Raul Quintana-Belmares

    (Instituto Nacional de Cancerología, Mexico City 1408, Mexico)

  • Álvaro Osornio-Vargas

    (Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada)

  • Pamela Ohman-Strickland

    (Department of Biostatistics Rutgers University School of Public Health, Piscataway, NJ 08854, USA)

  • Stephan Schwander

    (Environmental and Occupational Health Sciences Institute, Rutgers, Piscataway, NJ 08854, USA
    Department of Environmental and Occupational Health, Rutgers School of Public Health, Piscataway, NJ 08854, USA
    Department of Urban-Global Public Health, Rutgers University School of Public Health, Newark, NJ 07102, USA)

Abstract

Tuberculosis (TB) and air pollution both contribute significantly to the global burden of disease. Epidemiological studies show that exposure to household and urban air pollution increase the risk of new infections with Mycobacterium tuberculosis (M.tb) and the development of TB in persons infected with M.tb and alter treatment outcomes. There is increasing evidence that particulate matter (PM) exposure weakens protective antimycobacterial host immunity. Mechanisms by which exposure to urban PM may adversely affect M.tb -specific human T cell functions have not been studied. We, therefore, explored the effects of urban air pollution PM 2.5 (aerodynamic diameters ≤2.5µm) on M.tb-specific T cell functions in human peripheral blood mononuclear cells (PBMC). PM 2.5 exposure decreased the capacity of PBMC to control the growth of M.tb and the M.tb-induced expression of CD69, an early surface activation marker expressed on CD3 + T cells. PM 2.5 exposure also decreased the production of IFN-γ in CD3 + , TNF-α in CD3 + and CD14 + M.tb-infected PBMC, and the M.tb-induced expression of T-box transcription factor TBX21 (T-bet). In contrast, PM 2.5 exposure increased the expression of anti-inflammatory cytokine IL-10 in CD3 + and CD14 + PBMC. Taken together, PM 2.5 exposure of PBMC prior to infection with M.tb impairs critical antimycobacterial T cell immune functions.

Suggested Citation

  • Olufunmilola Ibironke & Claudia Carranza & Srijata Sarkar & Martha Torres & Hyejeong Theresa Choi & Joyce Nwoko & Kathleen Black & Raul Quintana-Belmares & Álvaro Osornio-Vargas & Pamela Ohman-Strickl, 2019. "Urban Air Pollution Particulates Suppress Human T-Cell Responses to Mycobacterium Tuberculosis," IJERPH, MDPI, vol. 16(21), pages 1-18, October.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:21:p:4112-:d:280167
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    Citations

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    Cited by:

    1. Yun-Peng Chen & Le-Fan Liu & Yang Che & Jing Huang & Guo-Xing Li & Guo-Xin Sang & Zhi-Qiang Xuan & Tian-Feng He, 2022. "Modeling and Predicting Pulmonary Tuberculosis Incidence and Its Association with Air Pollution and Meteorological Factors Using an ARIMAX Model: An Ecological Study in Ningbo of China," IJERPH, MDPI, vol. 19(9), pages 1-11, April.
    2. Ying Xiong & Meixia Yang & Zhengzhong Wang & Honglin Jiang & Ning Xu & Yixin Tong & Jiangfan Yin & Yue Chen & Qingwu Jiang & Yibiao Zhou, 2022. "Association of Daily Exposure to Air Pollutants with the Risk of Tuberculosis in Xuhui District of Shanghai, China," IJERPH, MDPI, vol. 19(10), pages 1-12, May.
    3. Yuqing Feng & Jing Wei & Maogui Hu & Chengdong Xu & Tao Li & Jinfeng Wang & Wei Chen, 2022. "Lagged Effects of Exposure to Air Pollutants on the Risk of Pulmonary Tuberculosis in a Highly Polluted Region," IJERPH, MDPI, vol. 19(9), pages 1-13, May.
    4. Miguel Ángel Aguilar-Jurado & Pedro Gil-Madrona & Juan Francisco Ortega-Dato & David Zamorano-García, 2019. "Effects of an Educational Glass Recycling Program against Environmental Pollution in Spain," IJERPH, MDPI, vol. 16(24), pages 1-16, December.

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