IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i20p3863-d275694.html
   My bibliography  Save this article

The Association Between Decompensated Liver Cirrhosis and Deep Neck Infection: Real-World Evidence

Author

Listed:
  • Ming-Shao Tsai

    (Department of Otolaryngology—Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
    Health Information and Epidemiology Laboratory, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan)

  • Geng-He Chang

    (Department of Otolaryngology—Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
    Health Information and Epidemiology Laboratory, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan)

  • Wei-Ming Chen

    (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan)

  • Chia-Yen Liu

    (Health Information and Epidemiology Laboratory, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan)

  • Meng-Hung Lin

    (Health Information and Epidemiology Laboratory, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan)

  • Pey-Jium Chang

    (Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan)

  • Tsung-Yu Huang

    (Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
    Division of Infectious Diseases, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan)

  • Yao-Te Tsai

    (Department of Otolaryngology—Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan)

  • Ching-Yuan Wu

    (Department of Traditional Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan
    School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan)

  • Cheng-Ming Hsu

    (Department of Otolaryngology—Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan
    School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan)

  • Yao-Hsu Yang

    (Health Information and Epidemiology Laboratory, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan
    Department of Traditional Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan
    School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan)

Abstract

Background: Deep neck infection (DNI) can progress to become a life-threatening complication. Liver cirrhosis, which is related to poor immune conditions, is a likely risk factor for DNI. This study investigated the risk and mortality of DNI in patients with decompensated liver cirrhosis (DLC). Methods: We performed a nationwide cohort study using the National Health Insurance Research Database (NHIRD) in Taiwan. We included a total of 33,175 patients with DLC between 2000 and 2013, from the Catastrophic Illness Patient Database, a subsection of the NHIRD, along with 33,175 patients without cirrhosis who were matched in a 1:1 proportion for age, sex, and socioeconomic status. The occurrence of DNI was the primary study outcome. The risk, treatment, and mortalities of DNI were evaluated in the study and comparison cohorts. Results: DLC Patients had a significantly higher incidence of DNI than noncirrhotic patients ( p < 0.001). The adjusted Cox proportional hazard regression showed that DLC was associated with a significantly higher risk of DNI (adjusted hazard ratio, 4.11; 95% confidence interval, 3.16–5.35, p < 0.001). The mortality rate in cirrhotic patients with DNI was not significantly higher than that in noncirrhotic patients with DNI (11.6% vs. 9.8%; p = 0.651). Conclusions: This study is the first to investigate the correlation between DLC and DNI. The study findings strongly indicate that DLC is an independent risk factor for DNI. Cirrhotic patients with DNI do not have a significantly poorer survival rate than noncirrhotic patients with DNI. Therefore, physicians should be alert to potential DNI occurrence in DLC patients. Besides this, intensive care and appropriate surgical drainage can yield similar survival outcomes in DLC-DNI and noncirrhosis-DNI patients.

Suggested Citation

  • Ming-Shao Tsai & Geng-He Chang & Wei-Ming Chen & Chia-Yen Liu & Meng-Hung Lin & Pey-Jium Chang & Tsung-Yu Huang & Yao-Te Tsai & Ching-Yuan Wu & Cheng-Ming Hsu & Yao-Hsu Yang, 2019. "The Association Between Decompensated Liver Cirrhosis and Deep Neck Infection: Real-World Evidence," IJERPH, MDPI, vol. 16(20), pages 1-11, October.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:20:p:3863-:d:275694
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/20/3863/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/20/3863/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Meng-Chang Ding & Cheng-Ming Hsu & Stanley Yung-Chuan Liu & Yi-Chan Lee & Yao-Hsu Yang & Chia-Yen Liu & Geng-He Chang & Yao-Te Tsai & Li-Ang Lee & Pei-Rung Yang & Hsueh-Yu Li & Ming-Shao Tsai, 2021. "Deep Neck Infection Risk in Patients with Sleep Apnea: Real-World Evidence," IJERPH, MDPI, vol. 18(6), pages 1-10, March.
    2. Geng-He Chang & Ang Lu & Yao-Hsu Yang & Chia-Yen Liu & Pey-Jium Chang & Chuan-Pin Lee & Yao-Te Tsai & Cheng-Ming Hsu & Ching-Yuan Wu & Wei-Tai Shih & Ming-Shao Tsai, 2021. "High Risk of Peritonsillar Abscess in End-Stage Renal Disease Patients: A Nationwide Real-World Cohort Study," IJERPH, MDPI, vol. 18(13), pages 1-10, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:20:p:3863-:d:275694. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.