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Pathologic Complete Response (pCR) and Survival of Women with Inflammatory Breast Cancer (IBC): An Analysis Based on Biologic Subtypes and Demographic Characteristics

Author

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  • Tithi Biswas

    (Department of Radiation Oncology, University Hospitals, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Charulata Jindal

    (Centre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, The University of Newcastle (UoN), Newcastle 2308, Australia)

  • Timothy L. Fitzgerald

    (Surgical Oncology, Maine Medical Center Cancer Institute, Scarborough, ME 04074, USA)

  • Jimmy T. Efird

    (Centre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, The University of Newcastle (UoN), Newcastle 2308, Australia
    Priority Research Centre for Generational Health and Ageing (PRCGHA), School of Medicine and Public Health, The University of Newcastle (UoN), Newcastle 2308, Australia)

Abstract

In this US-based study of the National Cancer Database (NCDB), we examined 8550 patients diagnosed with non-metastatic, invasive inflammatory breast cancer (IBC) who received surgery from 2004–2013. Patients were grouped into four biologic subtypes (HR + /HER 2 − , HR + /HER 2 + , HR − /HER 2 + , HR − /HER 2 − ). On average, women were 56 years of age at diagnosis and were followed for a median of 3.7 years. The majority were white (80%), had private health insurance (50%), and presented with poorly differentiated tumors (57%). Approximately 46% of the cancers were >5 cm. Most patients underwent mastectomy (94%) and received radiotherapy (71%). Differences by biologic subtypes were observed for grade, lymph node invasion, race, and tumor size ( p < 0.0001). Patients experiencing pathologic complete response (pCR, 12%) vs. non-pCR had superior 5-year overall survival (OS) (77% vs. 54%) ( p < 0.0001). Survival was poor for triple-negative (TN) tumors (37%) vs. other biologic subtypes (60%) ( p < 0.0001). On multivariable analysis, TN-IBC, positive margins, and not receiving either chemotherapy, hormonal therapy or radiotherapy were independently associated with poor 5-year survival ( p < 0.0001). In this analysis of IBC, categorized by biologic subtypes, we observed significant differential tumor, patient and treatment characteristics, and OS.

Suggested Citation

  • Tithi Biswas & Charulata Jindal & Timothy L. Fitzgerald & Jimmy T. Efird, 2019. "Pathologic Complete Response (pCR) and Survival of Women with Inflammatory Breast Cancer (IBC): An Analysis Based on Biologic Subtypes and Demographic Characteristics," IJERPH, MDPI, vol. 16(1), pages 1-15, January.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:1:p:124-:d:195009
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    References listed on IDEAS

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    1. Lia Scott & Lee R. Mobley & Dora Il’yasova, 2017. "Geospatial Analysis of Inflammatory Breast Cancer and Associated Community Characteristics in the United States," IJERPH, MDPI, vol. 14(4), pages 1-10, April.
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