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Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age

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  • Gang Cheng

    (Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Kaifu District, Changsha 410078, Hunan, China)

  • Tingting Sha

    (Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Kaifu District, Changsha 410078, Hunan, China)

  • Xiao Gao

    (Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Kaifu District, Changsha 410078, Hunan, China)

  • Xialing Wu

    (Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Kaifu District, Changsha 410078, Hunan, China)

  • Qianling Tian

    (Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Kaifu District, Changsha 410078, Hunan, China)

  • Fan Yang

    (Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Kaifu District, Changsha 410078, Hunan, China)

  • Yan Yan

    (Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Kaifu District, Changsha 410078, Hunan, China)

Abstract

At present, there is insufficient evidence on whether prenatal multi-micronutrient (MM) supplementation can be an antenatal nutritional intervention or not. This study aimed to explore the sustained effect of prenatal MM supplementation on early childhood health. A total of 939 mother–offspring pairs were followed up in the study between 2015 to 2018 in Changsha, China. Information was mainly collected through household surveys at the ages of 1, 3, 6, 8, 12, 18, 24, and 36 months. General linear models and generalized estimating equation models were used to estimate the effects of maternal prenatal MM compared with IFA supplementation on infant growth and development. Offspring of women who used prenatal MM compared with IFA supplements had lower weight-for-age z score (WAZ) (adjusted β: −0.23, 95% CI: (−0.40, −0.06)) and weight-for-length z score (WLZ) (adjusted β: −0.20, 95% CI: (−0.37, −0.02)) at 3 months old, but a reduced risk of obesity at birth (aRR: 0.30, 95% CI: 0.11–0.78) and being overweight at 3 months old (aRR: 0.52, 95% CI: 0.32–0.84). Moreover, offspring of women who used prenatal MM compared with IFA supplements had significantly higher scores for communication (adjusted β: 0.41, 95% CI: 0.61–0.21), gross motor (adjusted β: 0.68, 95% CI: 0.49–0.88), fine motor (adjusted β: 1.64, 95% CI: 1.45–1.84), problem solving (adjusted β: 0.29, 95% CI: 0.10–0.49), and personal–social (adjusted β: 0.90, 95% CI: 0.70–1.10) skills at 36 months old. Prenatal MM supplementation could result in better infant growth in the first few months of life and improve development scores at the age of 3 years compared with IFA supplementation.

Suggested Citation

  • Gang Cheng & Tingting Sha & Xiao Gao & Xialing Wu & Qianling Tian & Fan Yang & Yan Yan, 2019. "Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age," IJERPH, MDPI, vol. 16(15), pages 1-16, August.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:15:p:2744-:d:253609
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    References listed on IDEAS

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    1. Xialing Wu & Xiao Gao & Tingting Sha & Guangyu Zeng & Shiping Liu & Ling Li & Cheng Chen & Yan Yan, 2019. "Modifiable Individual Factors Associated with Breastfeeding: A Cohort Study in China," IJERPH, MDPI, vol. 16(5), pages 1-11, March.
    2. Tingting Sha & Xiao Gao & Cheng Chen & Ling Li & Qiong He & Xialing Wu & Gang Cheng & Qianling Tian & Fan Yang & Yan Yan, 2019. "Associations of Pre-Pregnancy BMI, Gestational Weight Gain and Maternal Parity with the Trajectory of Weight in Early Childhood: A Prospective Cohort Study," IJERPH, MDPI, vol. 16(7), pages 1-13, March.
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    Cited by:

    1. Gang Cheng & Tingting Sha & Xiao Gao & Qiong He & Xialing Wu & Qianling Tian & Fan Yang & Cai Tang & Xihong Wu & Qunhui Xie & Yan Yan, 2019. "The Associations between the Duration of Folic Acid Supplementation, Gestational Diabetes Mellitus, and Adverse Birth Outcomes based on a Birth Cohort," IJERPH, MDPI, vol. 16(22), pages 1-15, November.

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