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Increased Risk of Carotid Atherosclerosis in Male Patients with Chronic Periodontitis: A Nationwide Population-Based Retrospective Cohort Study

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  • Ching Tong

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
    Division of Endodontics & Periodontology, Department of Stomatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan)

  • Yu-Hsun Wang

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Yu-Chao Chang

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

Abstract

Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually caused by atherosclerosis. However, no studies have specifically evaluated the association between carotid atherosclerosis (CA) and chronic periodontitis (CP). This study was to investigate the role of CP in increasing the subsequent risk of CA in the overall Taiwanese population. We carried out this retrospective cohort study, employing data derived from the National Health Insurance Research Database. A total of 72,630 patients who were newly diagnosed with CP from 2001 to 2012 were selected. For a propensity-matched control group, 72,630 healthy patients without CP were picked at random, matched according to age, sex, and index year from the general population. Cox proportional hazard regression analysis, which included sex, age, and comorbidities, was adopted to assess the hazard ratio (HR) of CA between the CP cohort and non-CP cohort. The average ages of the CP and non-CP groups were 44.02 ± 14.63 years and 44.15 ± 14.41 years, respectively. The follow up durations were 8.65 and 8.59 years for CP and non-CP groups, respectively. The results demonstrated that 305 and 284 patients with newly diagnosed CA were found in the CP cohort and non-CP cohort, respectively. There was no significant difference of developing CA in the CP cohort compared with the non-CP cohort (adjusted HR) 1.01, 95% confidence interval (CI, 0.86–1.19). However, multivariate Cox regression analysis indicated that the male group had significantly higher incidence risk of CA (log rank p = 0.046). In conclusion, this nationwide retrospective cohort study indicated that male patients with CP exhibited a significantly higher risk of CA than those without CP.

Suggested Citation

  • Ching Tong & Yu-Hsun Wang & Yu-Chao Chang, 2019. "Increased Risk of Carotid Atherosclerosis in Male Patients with Chronic Periodontitis: A Nationwide Population-Based Retrospective Cohort Study," IJERPH, MDPI, vol. 16(15), pages 1-8, July.
  • Handle: RePEc:gam:jijerp:v:16:y:2019:i:15:p:2635-:d:251025
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    Citations

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    Cited by:

    1. Chia-Hao Liu & Yu-Chieh Lee & Jeff Chien-Fu Lin & I-San Chan & Na-Rong Lee & Wen-Hsun Chang & Wei-Min Liu & Peng-Hui Wang, 2019. "Radical Hysterectomy After Neoadjuvant Chemotherapy for Locally Bulky-Size Cervical Cancer: A Retrospective Comparative Analysis between the Robotic and Abdominal Approaches," IJERPH, MDPI, vol. 16(20), pages 1-19, October.
    2. Li-Chiu Yang & Yih-Jane Suen & Yu-Hsun Wang & Tai-Chen Lin & Hui-Chieh Yu & Yu-Chao Chang, 2020. "The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-10, January.
    3. Yung-Kai Huang & Li-Chiu Yang & Yu-Hsun Wang & Yu-Chao Chang, 2021. "Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study," IJERPH, MDPI, vol. 18(4), pages 1-10, February.
    4. Yung-Kai Huang & Yu-Hsun Wang & Yu-Chao Chang, 2020. "Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study," IJERPH, MDPI, vol. 17(10), pages 1-8, May.
    5. Ying-Ting Yeh & Yen-Shuo Tseng & Yi-Liang Wu & Shun-Fa Yang & Bo-Yuan Wang & Yu-Hsun Wang & Liang-Tsai Yeh & Ying-Tung Yeh & Chi-Ho Chan, 2022. "Risk of Peripheral Arterial Occlusive Disease with Periodontitis and Dental Scaling: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 19(16), pages 1-11, August.

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