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Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

Author

Listed:
  • Giannicola Iannella

    (Department of ‘Organi di Senso’, University “Sapienza”, Viale dell’Università 33, 00161 Rome, Italy)

  • Claudio Vicini

    (Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121 Forlì, Italy
    Department ENT and Audiology, University of Ferrara, Via Aldo Moro, 8, 44124 Ferrara, Italy)

  • Antonella Polimeni

    (Department of Oral and Maxillo Facial Sciences, University “Sapienza”, Via Caserta, 6, 00161 Rome, Italy)

  • Antonio Greco

    (Department of ‘Organi di Senso’, University “Sapienza”, Viale dell’Università 33, 00161 Rome, Italy)

  • Riccardo Gobbi

    (Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121 Forlì, Italy)

  • Filippo Montevecchi

    (Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121 Forlì, Italy)

  • Andrea De Vito

    (Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121 Forlì, Italy)

  • Giuseppe Meccariello

    (Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121 Forlì, Italy)

  • Giovanni Cammaroto

    (Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121 Forlì, Italy)

  • Giovanni D’Agostino

    (Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121 Forlì, Italy)

  • Annalisa Pace

    (Department of ‘Organi di Senso’, University “Sapienza”, Viale dell’Università 33, 00161 Rome, Italy)

  • Raffaella Cascella

    (Department of ‘Organi di Senso’, University “Sapienza”, Viale dell’Università 33, 00161 Rome, Italy)

  • Marco Brunori

    (Department of Cardiovascular, Respiratory, Nephrologic, Anaesthesiologic and Geriatric Sciences, Sapienza University, Viale dell’Università 33, 00161 Rome, Italy)

  • Cristina Anna Maria Lo Iacono

    (Department of Cardiovascular, Respiratory, Nephrologic, Anaesthesiologic and Geriatric Sciences, Sapienza University, Viale dell’Università 33, 00161 Rome, Italy)

  • Stefano Pelucchi

    (Department ENT and Audiology, University of Ferrara, Via Aldo Moro, 8, 44124 Ferrara, Italy)

  • Giuseppe Magliulo

    (Department of ‘Organi di Senso’, University “Sapienza”, Viale dell’Università 33, 00161 Rome, Italy)

Abstract

Background: To investigate the presence of laryngopharyngeal reflux in patients with obstructive sleep apnea (OSA) employing the salivary pepsin concentration method. To compare the results of pepsin concentration with the severity of the pathology. Methods: Seventy-five OSA patients (44 males, 31 females) were enrolled in the study. For each patient, the AHI (apnea–hypopnea index) and the BMI (body mass index) were initially evaluated. All the patients enrolled were assessed using the reflux symptom index (RSI) and the reflux finding score (RFS) in order to perform a clinical diagnosis of laryngopharyngeal reflux. In all patients a salivary sample was taken to estimate the presence of pepsin and its concentration. Results: The incidence of LPR (laryngopharyngeal reflux) in OSA patients, evaluated using the salivary pepsin concentration test (PEP-test), was found to be 32% of cases. Linear regression testing did not show any correlation between AHI and pepsin concentration in salivary samples ( p = 0.1). Conclusion: A high number of patients with OSA seem to show positivity for salivary pepsin, correlated to an LPR. There does not appear to be a correlation between the severity of apnea and the grade of salivary pepsin reflux. On the other hand, direct correlation between BMI and the value of pepsin in salivary specimens was observed.

Suggested Citation

  • Giannicola Iannella & Claudio Vicini & Antonella Polimeni & Antonio Greco & Riccardo Gobbi & Filippo Montevecchi & Andrea De Vito & Giuseppe Meccariello & Giovanni Cammaroto & Giovanni D’Agostino & An, 2019. "Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test," IJERPH, MDPI, vol. 16(11), pages 1-10, June.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:11:p:2056-:d:238695
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    Citations

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    Cited by:

    1. Giannicola Iannella & Giuseppe Magliulo & Cristina Anna Maria Lo Iacono & Giulia Bianchi & Antonella Polimeni & Antonio Greco & Andrea De Vito & Giuseppe Meccariello & Giovanni Cammaroto & Riccardo Go, 2020. "Positional Obstructive Sleep Apnea Syndrome in Elderly Patients," IJERPH, MDPI, vol. 17(3), pages 1-12, February.
    2. Giannicola Iannella & Giuseppe Magliulo & Antonio Greco & Marco de Vincentiis & Massimo Ralli & Antonino Maniaci & Annalisa Pace & Claudio Vicini, 2022. "Obstructive Sleep Apnea Syndrome: From Symptoms to Treatment," IJERPH, MDPI, vol. 19(4), pages 1-3, February.
    3. Giannicola Iannella & Bianca Vallicelli & Giuseppe Magliulo & Giovanni Cammaroto & Giuseppe Meccariello & Andrea De Vito & Antonio Greco & Stefano Pelucchi & Rossella Sgarzani & Ruggero Massimo Corso , 2020. "Long-Term Subjective Outcomes of Barbed Reposition Pharyngoplasty for Obstructive Sleep Apnea Syndrome Treatment," IJERPH, MDPI, vol. 17(5), pages 1-11, February.

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