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Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaM os )

Author

Listed:
  • Evelyn M. M. Wong

    (Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
    Division of Endocrinology and Metabolism, Department of Medicine, University Health Network and Sinai Health System, University of Toronto, Toronto, ON M5G 2C4, Canada
    Osteoporosis Program, University Health Network, Toronto, ON M5G 2C4, Canada
    Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5G 2C4, Canada)

  • George Tomlinson

    (Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5G 2C4, Canada
    Toronto General Hospital Research Institute, Toronto, ON M5G 2C4, Canada
    Division of General Internal Medicine, Department of Medicine, University Health Network and Sinai Health System, University of Toronto, Toronto, ON M5G 2C4, Canada)

  • Marsha M. Pinto

    (Osteoporosis Program, University Health Network, Toronto, ON M5G 2C4, Canada
    Institute of Medical Sciences, University of Toronto, Toronto, ON M5G 2C4, Canada)

  • Claudie Berger

    (Canadian Multicentre Osteoporosis Study Data Management Group, McGill University, Montreal, ON H4A 3S5, Canada)

  • Angela M. Cheung

    (Division of Endocrinology and Metabolism, Department of Medicine, University Health Network and Sinai Health System, University of Toronto, Toronto, ON M5G 2C4, Canada
    Osteoporosis Program, University Health Network, Toronto, ON M5G 2C4, Canada
    Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5G 2C4, Canada
    Toronto General Hospital Research Institute, Toronto, ON M5G 2C4, Canada)

  • Jerilynn C. Prior

    (Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
    Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
    School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    BC Women’s Health Research Institute, Vancouver, BC V6H 2N9, Canada)

Abstract

Women’s hot flushes and night sweats, collectively called vasomotor symptoms (VMS), are maximal (79%) in late perimenopause. The evidence describing whether VMS are associated with loss of areal bone mineral density (BMD) is mixed. We examined baseline and 2-year data for 1570 randomly selected women aged 43–63 in the Canadian Multicentre Osteoporosis Study (CaM os ), a prospective Canada-wide study; we used linear regression to assess the relationship of night sweats (VMSn) with BMD and its changes. Clinically important VMSn occurred for 12.2%. Women with VMSn were slightly younger (54.5 vs. 55.3 years, p = 0.02) and less likely to use sex steroid therapies (39.8% vs. 51.4%, p < 0.05). BMD at the lumbar spine (L1-4), femoral neck (FN) and total hip (TH) were similar between those with/without VMSn. In adjusted models, we did not find a significant association between VMSn and 2-year change in L1-4, FN and TH BMD. Age, reproductive status, weight, sex steroid therapy and smoking status were associated with 2-year change in BMD. Incident fractures over 2 years also did not differ by VMSn. Our analyses were restricted to VMSn and may not truly capture the relationship between VMS and BMD. Additional research involving VMS, bone loss and fracture incidence is needed.

Suggested Citation

  • Evelyn M. M. Wong & George Tomlinson & Marsha M. Pinto & Claudie Berger & Angela M. Cheung & Jerilynn C. Prior, 2018. "Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaM os )," IJERPH, MDPI, vol. 15(6), pages 1-13, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1079-:d:149131
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