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Association of Insulin Resistance with Bone Strength and Bone Turnover in Menopausal Chinese-Singaporean Women without Diabetes

Author

Listed:
  • Maria Kalimeri

    (A*STAR-NUS Clinical Imaging Research Centre, 14 Medical Drive, Singapore 117599, Singapore)

  • Francesca Leek

    (A*STAR-NUS Clinical Imaging Research Centre, 14 Medical Drive, Singapore 117599, Singapore)

  • Nan Xin Wang

    (Clinical Nutrition Research Centre, 14 Medical Drive, Singapore 117599, Singapore)

  • Huann Rong Koh

    (Clinical Nutrition Research Centre, 14 Medical Drive, Singapore 117599, Singapore)

  • Nicole C. Roy

    (Food Nutrition & Health Team, AgResearch Grasslands, Palmerston North 4442, New Zealand
    High-Value Nutrition, National Science Challenge, Liggins Institute, The University of Auckland, Auckland 1142, New Zealand
    Riddet Institute, Massey University, Palmerston North 4442, New Zealand)

  • David Cameron-Smith

    (Food Nutrition & Health Team, AgResearch Grasslands, Palmerston North 4442, New Zealand
    Riddet Institute, Massey University, Palmerston North 4442, New Zealand
    Liggins Institute, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand)

  • Marlena C. Kruger

    (Riddet Institute, Massey University, Palmerston North 4442, New Zealand
    School of Food and Nutrition, Massey Institute of Food Science and Technology, Massey University, Palmerston North 6420, New Zealand)

  • Christiani Jeyakumar Henry

    (Clinical Nutrition Research Centre, 14 Medical Drive, Singapore 117599, Singapore)

  • John J. Totman

    (A*STAR-NUS Clinical Imaging Research Centre, 14 Medical Drive, Singapore 117599, Singapore)

Abstract

Insulin resistance (IR) is accompanied by increased areal or volumetric bone mineral density (aBMD or vBMD), but also higher fracture risk. Meanwhile, imbalances in bone health biomarkers affect insulin production. This study investigates the effect of IR on proximal femur and lumbar spine BMD, femoral neck bending, compressive and impact strength indices (Composite Strength Indices) and circulating levels of parathyroid hormone (PTH), C-telopeptide of Type I collagen (CTx-1) and 25(OH) Vitamin D 3 , in a cohort of 97 healthy, non-obese, menopausal Chinese-Singaporean women. Lumbar spine aBMD was inversely associated with IR and dependent on lean body mass (LBM) and age. No such associations were found for vBMD of the third lumbar vertebra, aBMD and vBMD of the proximal femur, or circulating levels of PTH, CTx-1 and 25(OH) Vitamin D 3 . Composite Strength Indices were inversely associated with IR and independent of LBM, but after adjusting for fat mass and age, this association remained valid only for the impact strength index. Composite Strength Indices were significantly lower in participants with a high degree of IR. Our findings on IR and Composite Strength Indices relationships were in agreement with previous studies on different cohorts, but those on IR and BMD associations were not.

Suggested Citation

  • Maria Kalimeri & Francesca Leek & Nan Xin Wang & Huann Rong Koh & Nicole C. Roy & David Cameron-Smith & Marlena C. Kruger & Christiani Jeyakumar Henry & John J. Totman, 2018. "Association of Insulin Resistance with Bone Strength and Bone Turnover in Menopausal Chinese-Singaporean Women without Diabetes," IJERPH, MDPI, vol. 15(5), pages 1-11, April.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:5:p:889-:d:143885
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    Citations

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    Cited by:

    1. Jerilynn C. Prior, 2018. "Innovations in Women’s Bone Health—Appreciating Important “Bone Variables” Besides Estrogen," IJERPH, MDPI, vol. 15(9), pages 1-4, September.

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