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Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle

Author

Listed:
  • Jun-Won Heo

    (Department of Kinesiology, Inha University, Incheon 22212, Korea)

  • Su-Zi Yoo

    (Department of Kinesiology, Inha University, Incheon 22212, Korea)

  • Mi-Hyun No

    (Department of Kinesiology, Inha University, Incheon 22212, Korea)

  • Dong-Ho Park

    (Department of Kinesiology, Inha University, Incheon 22212, Korea)

  • Ju-Hee Kang

    (Department of Pharmacology and Medicinal Toxicology Research Center, Inha University School of Medicine, Incheon 22212, Korea)

  • Tae-Woon Kim

    (Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea)

  • Chang-Ju Kim

    (Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea)

  • Dae-Yun Seo

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea)

  • Jin Han

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea)

  • Jin-Hwan Yoon

    (Department of Kinesiology, Hannam University, Daejeon 34430, Korea)

  • Su-Jeen Jung

    (Department of Leisure Sports, Seoil University, Seoul 02192, Korea)

  • Hyo-Bum Kwak

    (Department of Kinesiology, Inha University, Incheon 22212, Korea)

Abstract

Obesity is characterized by the induction of skeletal muscle remodeling and mitochondria-mediated apoptosis. Exercise has been reported as a positive regulator of skeletal muscle remodeling and apoptosis. However, the effects of exercise on skeletal muscle remodeling and mitochondria-mediated apoptosis in obese skeletal muscles have not been clearly elucidated. Four-week-old C57BL/6 mice were randomly assigned into four groups: control (CON), control plus exercise (CON + EX), high-fat diet (HFD), and HFD plus exercise groups (HFD + EX). After obesity was induced by 20 weeks of 60% HFD feeding, treadmill exercise was performed for 12 weeks. Exercise ameliorated the obesity-induced increase in extramyocyte space and a decrease in the cross-sectional area of the skeletal muscle. In addition, it protected against increases in mitochondria-mediated apoptosis in obese skeletal muscles. These results suggest that exercise as a protective intervention plays an important role in regulating skeletal muscle structure and apoptosis in obese skeletal muscles.

Suggested Citation

  • Jun-Won Heo & Su-Zi Yoo & Mi-Hyun No & Dong-Ho Park & Ju-Hee Kang & Tae-Woon Kim & Chang-Ju Kim & Dae-Yun Seo & Jin Han & Jin-Hwan Yoon & Su-Jeen Jung & Hyo-Bum Kwak, 2018. "Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle," IJERPH, MDPI, vol. 15(10), pages 1-12, October.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:10:p:2301-:d:176896
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    References listed on IDEAS

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    1. Michael O. Hengartner, 2000. "The biochemistry of apoptosis," Nature, Nature, vol. 407(6805), pages 770-776, October.
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